lung function

November 13, 2018November 13, 2018

Inhaled Hypertonic Saline Eases CF Symptoms and Helps Infants Breathe Easier, Trial Finds

cystic fibrosis

Inhalation of hypertonic saline can help babies with cystic fibrosis to breathe better and relieve CF symptoms, according to a new trial. Researchers safely measured lung airflow in infants ... Read more

November 12, 2018November 12, 2018

Liver Disease Doesn’t Worsen Lung Function Decline in CF Patients, Study Reports

cystic fibrosis, News

Cystic fibrosis (CF) patients with liver disease do not experience greater lung function decline compared with CF patients without liver presentation, a study reports. The study, “Analysis of a large ... Read more

November 8, 2018November 8, 2018

Worse CF Lung Outcomes Linked with Mutations Causing Iron Overload Disorder, Study Finds

cystic fibrosis, News

Patients with cystic fibrosis (CF) who carry certain mutations in the HFE gene, which are also behind an iron overload disorder, have poorer lung function that declines faster and ... Read more

November 6, 2018November 6, 2018

#NACFC2018 – RPL554 Shows Promising Results in CF Studies

cystic fibrosis, News

Positive data from preclinical and Phase 2a studies evaluating the investigational cystic fibrosis (CF) treatment RPL554 were presented at the 2018 North American Cystic Fibrosis Conference (NACFC) in Denver, Colorado (Oct. ... Read more

October 31, 2018October 31, 2018

Santhera Starting Phase 1b/2a Trial Testing Potential CF therapy POL6014

cystic fibrosis, News

A Phase 1b/2a, dose-escalating clinical trial evaluating the effects of POL6014 in patients with cystic fibrosis (CF) was recently launched, according to Santhera Pharmaceuticals, developer of the investigational therapy. The ... Read more

October 30, 2018October 30, 2018

VX-445 Triple Combo Improves Lung Function in CF Patients with F508del Mutations, Phase 2 Trial Shows

cystic fibrosis, News

Adding the investigational therapy VX-445 to tezacaftor (VX-661) and Kalydeco (ivacaftor) led to a roughly 10 percent improvement in the lung function of cystic fibrosis (CF) patients with F508del mutations in the CFTR gene ... Read more

October 24, 2018October 24, 2018

PTI-808 and PTI-801 Combo Improves Lung Function in CF Patients, Phase 1 Data Show

cystic fibrosis, News

Treatment with a combo of Proteostasis Therapeutics’ investigational CFTR modulator therapies — PTI-808, a potentiator, plus PTI-801, a corrector — can promote significant improvements in lung function and reduction of sweat ... Read more

October 17, 2018October 15, 2018

We Need to Widen Inclusion Criteria for Cystic Fibrosis Clinical Trials

Columns, This Lung Life - a Column by Ella Balasa

As readers of my column, you know that I write about the journey of life and the emotions of living with cystic fibrosis (CF). This week, I want to ... Read more

August 30, 2018August 30, 2018

MRSA Difficult to Eradicate, Even With Multimodal Antibiotics, CF Study Finds

cystic fibrosis, News

Up to one month of treatment with inhaled vancomycin, the antibiotic of choice for treating most methicillin-resistant Staphylococcus aureus (MRSA) infections, together with a combination of oral and topical antibiotics, failed to ... Read more

August 22, 2018August 21, 2018

I Have Cystic Fibrosis, and CF Has Me

Columns, This Lung Life - a Column by Ella Balasa

I hear others say “I have CF. CF doesn’t have me.” This may be an accurate statement for some, the small percentage of patients who are not limited by ... Read more

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