Joana Fernandes, PhD,  —

Promising results of preclinical studies evaluating the effectiveness of SYGN113 to treat bacterial biofilms in the lungs of patients with cystic fibrosis (CF), and of SYGN303 to treat the gastrointestinal consequences of the disease, were presented at the North American Cystic Fibrosis Conference (NACFC) now taking place in Orlando. Bacterial biofilms are…

Results of the safety, stability, and effectiveness of Spyryx Biosciences‘ drug candidate SPX-101 for cystic fibrosis (CF) will be presented at the North American Cystic Fibrosis Conference (NACFC) Thursday through Saturday in Orlando, Florida. SPX-101 mimics the function of the protein SPLUNC1, which plays an important role in controlling airway…

A new device using Bluetooth technology, called eRapid, can administer inhaled therapies to patients with cystic fibrosis (CF) and alert doctors that patients have taken their medicine, improving their adherence to treatments. The findings come from a study conducted by researchers at Ventura County Medical Center in California. The study,…

The U.S. Food and Drug Administration (FDA) approved a new dose of Pertzye (pancrelipase) to specifically treat infants (up to one year of age) with exocrine pancreatic insufficiency (EPI) associated with cystic fibrosis (CF) or other conditions. The approval refers to a new capsule containing 4,000 USP units of lipase…

A preclinical study using animal models of cystic fibrosis (CF) showed that SPX-101, a treatment being developed by Spyryx Biosciences, effectively cleared lung mucus in the animals, regardless of the presence of genetic mutations that promote the development of the disease. Results of this study were presented by John Taylor, Spyryx’s president…

Treating patients with cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD), infected with the fungus Aspergillus fumigatus, with antifungal therapies may contribute to the adaptation and resistance of this microorganism, and exacerbate lung infection, a new study reported. This finding, in a report by medical researchers in the Netherlands, underscores the…

Results of a clinical trial evaluating Resunab (JBT-101) in a model of inflammation in healthy subjects indicated that this drug may be a treatment for chronic immune responses linked to tissue inflammation and cystic fibrosis (CF). The results were recently presented at this year’s 6th European Workshop on Lipid Mediators, that…

Certain molecules present in the sputum — “coughed-up” material from the trachea and lungs — can help to predict the onset of an inflammation attack in patients with cystic fibrosis (CF), a new study by researchers at the University of California reported. The study, “Metabolomics Of Pulmonary Exacerbations Reveals The Personalized Nature Of…

Two studies published in the Journal of Clinical Investigation (JCI) demonstrate the potential of pigs with cystic fibrosis (CF) — the ExeGen CFTR miniswine model — to test the effectiveness and workings of gene therapies for the disease. This animal research model was developed by Exemplar Genetics, a subsidiary…

A new study published in the journal Science Advances sheds light on the molecular mechanisms responsible for the pathology of cystic fibrosis (CF), and may assist in the development of targeted therapies against the disease. Researchers investigated the role of two proteins, KCNE3 and KCNQ1, and how they can contribute…