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January 15, 2019January 15, 2019

Immunotherapy May Be Promising Strategy to Treat Chronic Infections of P. aeruginosa in CF Patients

cystic fibrosis, News

Blocking the interaction between two molecules involved in immune restraining mechanisms — called PD-1 and PD-L1 — may be an effective therapeutic strategy to boost the immune system and ... Read more

January 14, 2019January 14, 2019

Eluforsen Improves CFTR Protein Function in CF Patients with F508del Mutations, Phase 1 Trial Shows

cystic fibrosis, News

An exploratory Phase 1 trial showed that repeated intranasal treatment with the therapy eluforsen improved CFTR protein activity in adults with cystic fibrosis (CF) carrying F508del mutations in both ... Read more

January 11, 2019January 11, 2019

WHO Approves Ensifentrine as Name for Potential Inhaled Treatment Now in Clinical Trials

cystic fibrosis, News

The World Health Organization (WHO) approved ensifentrine as the recommended name to identify the cystic fibrosis (CF) treatment candidate RPL554. Verona Pharma’s ensifentrine is an inhaled inhibitor of the enzymes phosphodiesterase ... Read more

January 10, 2019January 10, 2019

New Inhaled Carrier May Work for CF mRNA Therapy, Mouse Study Finds

cystic fibrosis, News

An inhaled form of messenger RNA (mRNA) with the potential to safely deliver therapeutics to the lungs of cystic fibrosis (CF) patients has been discovered by researchers at the ... Read more

January 8, 2019January 14, 2019

Vertex and Arbor Biotechnologies Collaborating to Develop Cystic Fibrosis Gene Therapies

cystic fibrosis, News

Vertex Pharmaceuticals and Arbor Biotechnologies have established a partnership to discover new proteins to advance the development of gene therapies for cystic fibrosis. The companies also plan to develop ... Read more

December 21, 2018January 10, 2019

Using Food as Medicine to Manage CF: A Nutritionist’s View

News

As a clinician, I have consulted with many patients over the years and have had the opportunity to be inspired and impacted by many. Most recently I had the ... Read more

December 21, 2018December 21, 2018

AzurRx Starts Phase 2 Clinical Trial Testing MS1819-SD in CF Patients With EPI

cystic fibrosis, News

AzurRx BioPharma announced it has started a Phase 2 clinical trial testing the safety, tolerability, and efficacy of MS1819 Spray Dried (MS1819-SD) therapy in cystic fibrosis (CF) patients with ... Read more

December 20, 2018December 20, 2018

Gene Expression Patterns in Blood May Lead to Patient-tailored CF Treatment, Study Finds

cystic fibrosis, News

Researchers tested blood samples from cystic fibrosis (CF) patients and identified distinct gene expression patterns that could lead to patient-tailored treatments, a study reports. The study, “Identification of molecular ... Read more

December 19, 2018December 19, 2018

CFF Aids Development of NO-based Therapy, BIOC51, for Resistant Bacteria, Vast Therapeutics Says

cystic fibrosis, News

Vast Therapeutics announced that it received funding from the Cystic Fibrosis Foundation (CFF) to support further development of BIOC51, the company’s investigative treatment for antibiotic-resistant bacteria, including Pseudomonas aeruginosa, that is often ... Read more

December 18, 2018December 18, 2018

New Dual-antibiotic Powder Inhalation More Effective Against Drug-resistant Bacteria, Researchers Say

cystic fibrosis, News

Purdue University researchers have invented a new way of delivering two antibiotics (colistin and ciprofloxacin) deep into the lungs of cystic fibrosis (CF) patients, enabling much more effective killing of antibiotic-resistant ... Read more

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