Patricia Inácio, PhD, science writer —

Changes in two human voice parameters may help identify poor control of blood sugar levels in people with cystic fibrosis (CF) who have CF-related diabetes (CFRD), a pilot study reported. Lower measures on these parameters, known as fundamental frequency variation and noise-to-harmonic ratio, were linked with higher glucose,…

Children and adolescents with cystic fibrosis (CF) commonly have procedural anxiety — a sudden and excessive fear of a medical procedure leading to acute stress or avoidance — that’s associated with treatment resistance, according to a recent study. Parents and caregivers reported three out of four children view at…

The Phase 2 SPAN clinical trial of a new formulation of adrulipase in treating exocrine pancreatic insufficiency (EPI) in adults with cystic fibrosis (CF) has reached more than half of its target enrollment. Enrollment is ongoing at three U.S. sites, one each in Florida, Illinois, and Nevada. CF…

Monitoring the concentration of antibiotics in the blood — a clinical practice called therapeutic drug monitoring — was linked to fewer pulmonary exacerbations and less lung function decline in people with cystic fibrosis (CF), a small study reports. The study, “Therapeutic drug monitoring in cystic fibrosis…

Treatment with Orkambi (lumacaftor/ivacaftor) for six months lessened airway inflammation and enhanced airway bacterial diversity in people with cystic fibrosis (CF), but only when administered before patients were chronically infected with the bacterium Pseudomonas aeruginosa, a study has found. The findings suggest that “CFTR modulators [such as Orkambi] should…

A project that dissects the molecular proceses that allow bacteria of the Burkholderia cepacia complex to attach to cells was awarded a $400,125 grant from the National Institutes of Health (NIH). These bacteria are known to cause serious infections in people with cystic fibrosis (CF). The grant was awarded to Tung…

American Airlines and its partners announced having raised $1.1 million for the Cystic Fibrosis Foundation (CFF) during the annual American Airlines Celebrity Ski event. The event, running for 38 years, has collected more than $45 million in support of the foundation’s goal of a cure for cystic fibrosis (CF). Last year’s…

Trikafta significantly improved the lung function of cystic fibrosis patients after only two weeks of treatment, with the benefits sustained after nearly four months, according to real-world data from a single center in Austria. “Early LCI [lung clearance index] measurements can help to assess the patient’s response to this…

The first two patients have been dosed in the SPAN clinical trial testing a new formulation of adrulipase, a yeast-derived enzyme, to treat exocrine pancreatic insufficiency (EPI) in adults with cystic fibrosis (CF). The open-label Phase 2 study (NCT05719311) is enrolling adult patients at three sites, one each in Florida, Illinois,…

AP-PA02, an experimental phage therapy for people with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa respiratory infections, was well tolerated and reduced the bacterial load in the lungs, according to top-line results from a Phase 1b/2a trial. High doses of AP-PA02 were associated with durable reductions in bacterial load in the SWARM-Pa study. Pharmacokinetics data,…