Patrícia Silva, PhD,  director of science content—

Dutch pharmaceutical company ProQR Therapeutics now has two key patents protecting its first-in-class ribonucleic acid (RNA)-based oligonucleotide QR-010 for the treatment of cystic fibrosis (CF) in the United States and Europe. The patents are valid until at least July 2033. The new U.S. patent, announced April 3, covers methods of targeting…

Researchers from Queen’s University Belfast in Northern Ireland have not only discovered why antibiotics are becoming less effective at treating infections in cystic fibrosis (CF) patients — but have also found a potential solution: fat-soluble vitamins. Lung infections, mostly those caused by bacteria, are a serious problem for people with CF and are…

Galapagos initiated a Phase 1 trial to evaluate its investigational drug GLPG3067 for cystic fibrosis (CF), triggering a $7.5 million milestone payment from AbbVie, its collaboration partner. Galapagos and AbbVie began a global collaboration in September 2013 to discover, develop and commercialize potentiator and corrector molecules for the…

Aeolus Pharmaceuticals has released preliminary results from a study suggesting that AEOL 20415 could treat antibiotic-resistant bacteria, protecting the lungs in cystic fibrosis (CF). The company said its drug reduced infection, improved body weight and reduced the presence of white blood cells (macrophages and lymphocytes) in an animal model of CF. Brian Day, PhD,…

Canadians with cystic fibrosis (CF) live 10 years longer than Americans with the disease, a study shows. The life span of the average Canadian with CF was 50.9 years, versus 40.6 years for the average American, according to Anne Stephenson of St. Michael’s Hospital, the lead author of the study.

The University of Pittsburgh has agreed to conduct a Phase 1 and 2 clinical trial of Aries Pharmaceuticals‘ AIR001 for treating Pseudomonas aeruginosa bacteria infections in patients with cystic fibrosis (CF). Researchers from the university and the University of Pittsburgh Medical Center will work together on the open-label safety and proof-of-concept trial. Aries, a…

Sizable doses of a powerful class of antibiotics used to treat cystic fibrosis (CF) can accumulate over time to increase the risk of permanent hearing loss, according to a study. Previous research had shown an association between aminoglycosides and hearing loss. The new study is the first to address both daily…

Spyryx Biosciences has marked Feb. 28, Rare Disease Day, by announcing it will initiate a Phase 1b study to assess the safety of its SPX-101 in cystic fibrosis (CF) patients. SPX-101 is an experimental peptide designed to block the function of the lungs’ sodium channels, which move sodium and water from the…

Spyryx Biosciences successfully completed a Phase 1 clinical trial of its lead compound, SPX-101, in healthy volunteers and is now planning a Phase 2 study in patients with cystic fibrosis (CF). SPX-101 is an inhaled SPLUNC1-derived peptide created to regulate epithelial ion channels in the airways. The drug was…

Three Stanford University School of Medicine researchers have won grants to advance the development of stem cell-based therapies, including gene editing, for cystic fibrosis (CF), autoimmune disorders and liver disease. The grants are part of $20.5 million awarded to 11 researchers by the California Institute for Regenerative Medicine (CIRM) during the current…