Yedida Y Bogachkov PhD,  —

Risk factors for obstructive sleep apnea (OSA) — a condition in which airflow is blocked intermittently during sleep — differ between children and adults with cystic fibrosis (CF), according to a study. Upper airway conditions, such as enlarged tonsils and inflamed sinuses, appear to be important risk factors for…

Children with cystic fibrosis (CF) have significantly higher level of fibrocytes — cells associated with diseases marked by fibrosis or scarring — in their bloodstream relative to healthy children, a study reported. Findings further revealed that these fibrocyte levels were lower during CF exacerbations than stable disease, and lower…

The Cystic Fibrosis Foundation announced a $3.5 million investment in Pulmocide to support the company in developing an inhaled medication, opelconazole, to prevent fungal infections — specifically Aspergillus — in lung transplant patients. This funding will go toward a planned, multicenter Phase 2 clinical trial of opelconazole to…

Urinary incontinence, known to affect both girls and women with cystic fibrosis (CF), is increasingly prevalent as these patients age, and coughing or sneezing were common triggers among adults who took part in a study at a single site in Italy. Incontinence during physical exercise was also fairly common…

Molecules produced by the environmental bacteria Pseudomonas aeruginosa, called alkyl-quinolones derivatives — which regulate bacterial gene activity and act in cell-to-cell communication — may be useful markers for better management of patients with cystic fibrosis (CF), a study suggests. These derivatives also may enable a more clear definition…

Despite longer hospital stays and higher costs, adults with cystic fibrosis (CF) do not have a greater risk of death from surgery to remove the gallbladder — called a cholecystectomy — compared with people who do not have CF, a study reported. “Importantly, we found that cholecystectomy had very…

A retrospective study by the National Institutes of Health (NIH) suggests that healthcare costs for those with rare diseases have been underestimated, possibly being three to five times higher than for those without rare diseases. This study provides evidence of the potential effect rare diseases may have on public health…

The Cystic Fibrosis (CF) Foundation has invested $3 million in Armata Pharmaceuticals to support development of AP-PA02, a bacteriophage now being evaluated in a clinical trial for its ability to treat respiratory infections caused by Pseudomonas aeruginosa in people with cystic fibrosis (CF). “We are pleased by…

Young children with cystic fibrosis (CF), relative to age-matched peers with disorders also affecting the lungs, show differences in bacterial communities and inflammation of the lower airways starting at around age 2, a study reported. A lesser variety of bacterial classes and more inflammation in the lower airways —…

Although person-to-person transmission is possible, most cystic fibrosis (CF) patients infected with Mycobacterium avium complex (MAC) do not share similar strains, according to a study of patients at U.S. care centers. Researchers found high genetic similarity between isolates of MAC across some people followed at the same CF centers.