POL6014 is an investigational, highly potent, and reversible inhibitor of human neutrophil elastase (hNE). The experimental therapy can be formulated as an aerosol or dry powder formulation as a treatment for lung inflammation in cystic fibrosis (CF) patients.

Neutrophil elastase is a type of protein associated with inflammation in the lungs. Blocking the function of neutrophil elastase can minimize tissue destruction and decrease of inflammation within the airway of people with CF.

How POL6014 works

Human neutrophil elastase (hNE) is a key target for the treatment of respiratory conditions such as CF, chronic obstructive pulmonary disease (COPD), and alpha-1-antitrypsin deficiency (AATD). POL6014 is a selective and reversible inhibitor of hNE.

CF is characterized viscous secretions and bacterial lung inflammation that is dominated by neutrophils. These neutrophils become active and eventually die, liberating enzymes (proteases) that cause damage to structural, cellular and soluble components of the pulmonary environment. The neutrophil elastase enzyme is the most prominent protease released in the lungs of people with cystic fibrosis, playing a key role in the disease.

POL6014 studies

Preclinical pharmacological studies have shown that the aggressive and tissue degrading enzyme neutrophil elastase is inhibited by Polyphor’s POL6014 therapy candidate. It has shown high efficacy in animal models with respiratory diseases.

After inhalation, POL6014 reaches high concentrations in the lungs with a low blood concentration, reducing the risk of side-effects.

Exploratory toxicology studies suggest that POL6014 is well tolerated and safe when chronically inhaled as an aerosol.

POL6014 is still in Phase 1 clinical development.

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