Theradux (formerly OrPro and ORP-100) is an experimental biologic drug derived from a modified form of thioredoxin, a natural airway enzyme that acts to thin mucus in the lungs by preventing excess molecular bonds from forming in mucus layers. Thinner mucus is more easily cleared from the airways of people with cystic fibrosis (CF).1

 How Theradux works

Theradux (modified human thioredoxin-1) represents a new class of inhaled therapies that target structural changes in the mucus of CF patients through a pH-independent mechanism that prolongs activity and separates the drug in the mucus layer. Older mucolytic-reducing agents that break up mucus lose much of their potency in airways due to the low pH there, and are rapidly absorbed in the body, potentially resulting in systemic side effects. Theradux, in a nebulized form, is designed to go directly to the lungs to lower absorption elsewhere and be more effective. It relaxes abnormally stiffened mucus with the goal of restoring mucus transport and clearance.

Theradux is expected to work both alone and in conjunction with Cystic Fibrosis Transmembrane Regulator (CFTR) modifier therapies to alter the course of CF progression. It is being developed by OrPro Therapeutics.

OrPro/Theradux for cystic fibrosis

Results of in vivo and in vitro preclinical experiments involving Theradux were presented at the 2015 North American Cystic Fibrosis Foundation Conference. That data confirmed the treatment’s mucus-binding mechanism, and demonstrated no toxicity or inflammation in acute aerosol-inhalation studies.

In a poster presentation at that same conference in 2016, OrPro announced results of a preclinical study involving patient samples at the University of Alabama at Birmingham. Theradux was reported to be at least twice as effective in increasing mucus transport as Pulmozyme (dornase alfa), a standard of care mucolytic for CF treatment.

 

Cystic Fibrosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

 

Patent Granted to OrPro Therapeutics’ Lead Candidate Theradux™ for Treatment of Cystic Fibrosis

OrPro Therapeutics, Inc. has announced it has been granted a patent by the US Patent and Trademark Office (USPTO) for its lead candidate Theradux™, covering its unique treatment ability for cystic fibrosis (CF). The company has been developing a treatment pipeline based on thioredoxin, a naturally secreted protein with enzymatic activity known to have anti-inflammatory and anti-oxidative properties. Its […]

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