The study (NCT04488705) will assess the safety and tolerability of EDT002 in ascending single and multiple doses in healthy people as compared with a matching placebo. It is due to conclude in December.
“We are excited to have begun the clinical stage of development for ETD002,” John Ford, PhD, CEO of Enterprise Therapeutics, said in a press release. The therapy “has the potential to significantly increase the quality of life for people living with CF, for many of whom existing therapies are not effective.”
ETD002 is designed to boost — or potentiate — the activity of TMEM16A, a chloride channel found on the surfaces of cells in airway tissues, where it helps to regulate the amount of salt and fluids.
ETD002 enhanced the activity of TMEM16A in preclinical studies, thereby increasing fluid flow into the airways, as well as promoting mucus thinning and clearance, the company reports. Excessive mucus buildup in the airways is one of the main causes of breathing difficulty in CF patients, and raises the risk of infection.
CFTR modulation is another available and approved approach to treat CF. These therapies largely aim to correct mutations found in the CFTR (cystic fibrosis transmembrane conductance regulator) gene, which is the defective gene causing CF. Because of their specificity to certain mutations however, they are not always available or effective for all CF patients.
TMEM16A potentiation works regardless of a patient’s CFTR mutational status, making this approach applicable to all with CF, and potentially to patients with other lung diseases.
“Although CFTR modulators have successfully demonstrated improved clinical outcomes in those genetically suited to these therapies, we are hopeful that TMEM16A potentiation via ETD002 will provide clinical benefit to the many people with CF who do not share these CFTR mutations,” David Morris, MD, Enterprise’s chief medical officer, said.
ETD002 is expected to work both as a single therapy and in combination with other therapies, including those that repair the mutated CFTR.
“We look forward to generating our first data in human volunteers over the next few months and are grateful to the subjects and investigators who are helping us to advance this novel treatment for individuals with CF,” Morris concluded.
The trial, which seeks to enroll about 88 adult participants, is currently recruiting in the U.K. More information can be found here. The trial is supported by a Therapeutics Development Award from the Cystic Fibrosis Foundation.
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