Ana Pamplona, PhD,  —

A new study revealed that adaptive changes in Pseudomonas aeruginosa may exacerbate pulmonary inflammation and contribute to the pathogenesis and progression of chronic lung disease in the context of cystic fibrosis. The study entitled “Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses” was published in July in the Science Advances journal.

A new study entitled “A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus” published in the Scientific Reports journal by researchers from the PLUS Project for Medical Science and Yonsei University College of Medicine in Seoul, Korea, identified a genetic element that codifies…

Concert Pharmaceuticals will present data from a Phase 1 single ascending dose trial of experimental CF therapy CTP-656, a next generation potentiator developed for the treatment of cystic fibrosis during the 29th Annual North American Cystic Fibrosis Conference this week in Phoenix, Arizona. The study being presented is entitled ”…

A new study on the association between proteases and anti-proteases during Cystic fibrosis entitled “Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy” was published this June in Mediators of Inflammation. Cystic fibrosis (CF) is the…

A new study revealed that microRNA16 — a small non-coding RNA genes that regulates gene expression — can restore the F508del-CFTR protein function in airway cell lines and primary cultures of differentiated human bronchial epithelia from F508del homozygotes that express mutant CFTR protein endogenously. The finding is significant, as…

A new study on the clinical outcomes of cystic fibrosis revealed that patients infected only by Staphylococcus aureus infection in the absence of Pseudomonas aeruginosa led to milder disease. The study entitled “Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients” was published…

Researchers from The University of Texas at Austin recently revealed that the pathogenic bacteria Pseudomonas aeruginosa has the capacity to inhibit its own growth and the growth of antibiotic-resistant mutants. The study entitled “The spatial profiles and metabolic capabilities of microbial…

During the American Thoracic Society 2015 International Conference being held in Denver, Colorado, 15-20 of May, researchers from Oregon State University, Corvallis (OSU), and Aradigm Corporation will present a study entitled “Treatment of Mycobacterium Avium Subsp Hominissuis (MAH) Lung Infections with Liposome-Encapsulated Ciprofloxacin Resulted in Significant Decrease in Bacterial Load in the…

Researchers have discovered an association between Cystic Fibrosis and infection with the parasite Toxoplasma gondii. The study entitled “Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia” was published in the Proceedings of the National…

A new clinical study showed that AffloVest®, portable High Frequency Chest Wall Oscillation (HFCWO) vest, improved lung function scores in a cohort of adolescents with Cystic fibrosis. The study, entitled “An evidence-based study of adolescents with cystic fibrosis demonstrated that AffloVest® by International Biophysics contributed to improved…