Andrea Lobo, PhD,  science writer—

A Phase 1b trial assessing the safety of RCT2100, Recode Therapeutics’ inhaled therapy candidate for people with cystic fibrosis (CF), has now dosed its first patient in the U.S. The trial already was underway in Europe. RCT2100 is being developed for patients who do not respond to or…

A cystic fibrosis (CF) therapy slightly but significantly increased diversity in the lung microbiome, the community of microorganisms found in the lungs, in adolescents with the disease, a study in Switzerland found. Treatment with Trikafta was specifically linked to an increase in commensal bacteria, those commonly present in healthy…

A clinical trial assessing the safety and tolerability of CMTX-101, an antibody-based therapy for cystic fibrosis (CF) lung infections, has started its second part. Phase 2a of the Phase 1b/2a trial (NCT06159725) aims to enroll up to 41 adults with CF at several sites in the U.S., treatment developer…

The abundance of Pseudomonas bacteria and related virulence factors in the lungs of people with cystic fibrosis (CF) after a transplant may raise their risk of a progressive decline in lung function and organ rejection, according to a recent study. Virulence is the ability of a microorganism to cause…

The 10th Annual Glow Ride for Cystic Fibrosis (CF), held Sept. 21 at Hermosa Beach, California, exceeded expectations by raising more than $65,700 to support families experiencing financial difficulties due to extended hospital stays. That’s according to Claire’s Place Foundation, a nonprofit that provides support to children with…

An agency of the National Institutes of Health has awarded funding up to $7 million to researchers at the University of California (UC) to study the use of probiotics to treat lung infections in people with cystic fibrosis (CF). The funding comes from the Advanced Research Projects Agency…

Lung function decline slowed consistently over five years with Kalydeco (ivacaftor) treatment in adults and children with cystic fibrosis (CF), a real-world study in the U.S. shows. “Overall, these results expand on those from prior studies and show that [Kalydeco] has a meaningful and sustained impact on reducing…

More severe lung disease and using inhaled corticosteroids are associated with shorter telomere length, a sign of cellular aging, in immune cells from people with cystic fibrosis (CF), a study suggests. Telomeres are stretches of repetitive DNA that protect the ends of chromosomes, the long strings of DNA that…

Most people with cystic fibrosis (CF) who carry mutations that make them ineligible for CFTR modulators are prescribed medications that improve mucus thinning and clearance. Antibiotic use is also high, and because most patients had pancreatic insufficiency, treatment with pancreatic enzyme replacement therapy is also common. That’s according…

Having COVID-19 had no clinically meaningful impact on lung function and nutritional status for people with cystic fibrosis in the year after an infection, a study across 33 countries indicates. According to the researchers, the “study is [a] global representation of the impact of COVID-19 on the health of…