Andrea Lobo, PhD, science writer —

Lung function decline slowed consistently over five years with Kalydeco (ivacaftor) treatment in adults and children with cystic fibrosis (CF), a real-world study in the U.S. shows. “Overall, these results expand on those from prior studies and show that [Kalydeco] has a meaningful and sustained impact on reducing…

More severe lung disease and using inhaled corticosteroids are associated with shorter telomere length, a sign of cellular aging, in immune cells from people with cystic fibrosis (CF), a study suggests. Telomeres are stretches of repetitive DNA that protect the ends of chromosomes, the long strings of DNA that…

Most people with cystic fibrosis (CF) who carry mutations that make them ineligible for CFTR modulators are prescribed medications that improve mucus thinning and clearance. Antibiotic use is also high, and because most patients had pancreatic insufficiency, treatment with pancreatic enzyme replacement therapy is also common. That’s according…

Having COVID-19 had no clinically meaningful impact on lung function and nutritional status for people with cystic fibrosis in the year after an infection, a study across 33 countries indicates. According to the researchers, the “study is [a] global representation of the impact of COVID-19 on the health of…

The U.S. Food and Drug Administration (FDA) has cleared a Phase 2 clinical trial testing ARCT-032, an inhaled therapy candidate, in people with cystic fibrosis (CF). Arcturus Therapeutics, the therapy’s developer, did not announce when the trial is expected to start. “The study is designed to evaluate the…

A report described episodes of skin rash associated with joint pain and inflammation, known as dermatitis-arthritis syndrome, in four females with cystic fibrosis (CF). The patients had similar symptoms, including pink, swollen, itching skin eruptions associated with joint pain. The researchers proposed cystic fibrosis dermatitis arthritis syndrome as a…

A researcher at the University of California, Los Angeles (UCLA) has been awarded the Elizabeth Nash Postdoctoral Fellowship to develop a targeted cystic fibrosis (CF) gene therapy delivery system, the university announced. The two-year, $65,000-per-year fellowship, awarded annually by the Cystic Fibrosis Research Institute to support new…

Treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) may ease anxiety and depression symptoms in adults with cystic fibrosis (CF), a study found. A higher proportion of patients experienced a clinically significant easing in both anxiety and depression symptoms than those who saw their symptoms worsen. Those with clinically significant changes in…

Most infants with cystic fibrosis (CF) must be fed fortified milk, that is, breast milk, formula, or a combination of both, within the first six months of life to achieve normal growth by age 3, a study suggests. This lets babies receive all the benefits from breast milk, plus…

About one-quarter of men with cystic fibrosis (CF) have low testosterone levels, according to a new study that sought to assess the prevalence of this sexual health issue in males with the genetic disease. Neither age nor the time of day when testosterone measurements were taken influenced the levels…