Andrea Lobo, PhD,  science writer—

Inogen has acquired Physio-Assist, including Simeox, a technology for airway clearance and mucus management in people with cystic fibrosis (CF). The company will continue marketing Simeox in Europe, Asia, and the Middle East, while pursuing regulatory clearance in the U.S. This acquisition will expand Inogen’s portfolio of…

Infections with Staphylococcus aureus small colony variants, known as SCVs, are highly prevalent in people with cystic fibrosis (CF) — and linked to the previous use of the broad-spectrum antibiotic trimethoprim sulfamethoxazole, a systematic literature review has found. SCVs are slow-growing bacteria that are associated with higher rates of chronic…

An increase in body mass index (BMI) in people with cystic fibrosis (CF) under Kaftrio therapy may not be attributable to increased energy intake, according to a new U.K. study. Instead, gains in BMI, a measure of body fat, might reflect other factors, such as different energy requirements…

Anxiety and depression are more likely in younger cystic fibrosis (CF) patients with CF-related diabetes and more evident mental health challenges, a long-term study in teenagers and young adults reported. Poorer lung function is considered to affect mental health with CF, and the lung health of these patients…

The first patient has been dosed in a Phase 1 clinical trial of KB407, Krystal Biotech’s investigational gene therapy for people with cystic fibrosis (CF) regardless of the type of disease-causing CFTR gene mutation. The Phase 1 CORAL-1/US study (NCT05504837) is recruiting up to 20 adults with…

The presence of intestinal metabolites called bile acids in the airways of 1-year-old children genetically diagnosed with cystic fibrosis (CF) is significantly associated with early disease mechanisms and worse clinical outcomes, according to a study in Australia. These include increased levels of airway inflammation biomarkers, greater structural lung damage,…

Kaftrio (elexacaftor, tezacaftor, and ivacaftor) safely and effectively eases structural lung damage and improves lung function and the quality of life for people with cystic fibrosis (CF) who have advanced lung disease. That’s according to data from a compassionate use program in the Netherlands that let patients with severely…

Antibiotic resistance is high among cystic fibrosis (CF) patients infected with Staphylococcus aureus (S. aureus), according to a recent study. There was “high resistance to most of the antibiotics studied,” researchers say, with the highest observed for the antibiotics erythromycin and clindamycin, while the lowest resistance was seen with…

Reducing the dose of Kaftrio (elexacaftor, tezacaftor, and ivacaftor) should be considered for cystic fibrosis (CF) patients who report cognitive and psychological side effects, a study in Ireland suggests. Such patients should have an individualized dosage to minimize side effects while maintaining CFTR modulator therapy. “Dose reduction…

The Cystic Fibrosis Foundation is funding up to $3.9 million to TB Alliance to conduct preclinical studies of a compound that could be used to treat infections caused by nontuberculous mycobacteria (NTM) in people with cystic fibrosis (CF). These infections often require antibiotic treatment for more…