Lindsey Shapiro, PhD, science writer —

Cilia, the structures on the surface of respiratory cells that help propel mucus out of the airways, have altered movement patterns in people with cystic fibrosis (CF), a study from Belgium found. The researchers believe these abnormalities likely stem from inflammation and contribute to impaired mucociliary clearance (MCC) in…

There could be many genes beyond CFTR that influence cystic fibrosis (CF) severity and treatment responses, according to a review study. Across 70 different studies, dozens of these so-called genetic modifiers were found to affect the severity of various CF symptoms. Mutations in a few of them were…

In laboratory experiments, a team of researchers in Belgium identified a few strategies that might help prevent bacteria from forming treatment-resistant clusters called biofilms that are believed to underlie chronic rhinosinusitis (CRS) — an inflammatory condition affecting the nasal passages and…

Long-term treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) led to significant gains in lung function and nutritional status for cystic fibrosis (CF) patients with advanced lung disease, a real-world analysis shows. The improvements weren’t as large as those seen in patients with milder lung disease, but the findings demonstrate the…

Treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) cut sweat chloride levels in half among people with cystic fibrosis (CF), according to a real-world Danish study. Still, sweat chloride levels — a known biomarker of treatment responses in CF — were variable, and some treated patients still had levels out of the…

The real-world use of Kalydeco (ivacaftor) effectively eased disease severity in people with cystic fibrosis (CF) who had certain disease-causing mutations, according to a study that included patients with mutations for which Kalydeco was approved in the U.S. in 2017 based largely on laboratory data. “This study adds…

An Emory University program has been awarded $2 million toward optimizing the effectiveness of U.S. newborn screening programs, which help identify serious health conditions such as cystic fibrosis (CF) at birth. The four-year funding opportunity comes through a cooperative agreement with the U.S. Health Resources and Services Administration…

Researchers have uncovered a mechanism by which Pseudomonas aeruginosa and Aspergillus fumigatus — two common infection-causing microbes in the lungs of people with cystic fibrosis (CF) — are able to…

Families in the U.S. living with cystic fibrosis (CF) who’ve been affected by food insecurity feel that financial constraints imposed by the disease contribute to the problem and that government support programs are insufficient, interviews with patients and caregivers suggest. Those interviewed report feeling stigma and embarrassment…

A disease found in dogs where abnormally thick mucus accumulates in the gallbladder — called a mucocele — is characterized by altered levels and function of the CFTR protein that’s also faulty in cystic fibrosis (CF) patients, according to recent research. In contrast to the disease in humans, which…