Lindsey Shapiro, PhD, science writer —

In laboratory experiments, a team of researchers in Belgium identified a few strategies that might help prevent bacteria from forming treatment-resistant clusters called biofilms that are believed to underlie chronic rhinosinusitis (CRS) — an inflammatory condition affecting the nasal passages and…

Long-term treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) led to significant gains in lung function and nutritional status for cystic fibrosis (CF) patients with advanced lung disease, a real-world analysis shows. The improvements weren’t as large as those seen in patients with milder lung disease, but the findings demonstrate the…

Treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) cut sweat chloride levels in half among people with cystic fibrosis (CF), according to a real-world Danish study. Still, sweat chloride levels — a known biomarker of treatment responses in CF — were variable, and some treated patients still had levels out of the…

The real-world use of Kalydeco (ivacaftor) effectively eased disease severity in people with cystic fibrosis (CF) who had certain disease-causing mutations, according to a study that included patients with mutations for which Kalydeco was approved in the U.S. in 2017 based largely on laboratory data. “This study adds…

An Emory University program has been awarded $2 million toward optimizing the effectiveness of U.S. newborn screening programs, which help identify serious health conditions such as cystic fibrosis (CF) at birth. The four-year funding opportunity comes through a cooperative agreement with the U.S. Health Resources and Services Administration…

Researchers have uncovered a mechanism by which Pseudomonas aeruginosa and Aspergillus fumigatus — two common infection-causing microbes in the lungs of people with cystic fibrosis (CF) — are able to…

Families in the U.S. living with cystic fibrosis (CF) who’ve been affected by food insecurity feel that financial constraints imposed by the disease contribute to the problem and that government support programs are insufficient, interviews with patients and caregivers suggest. Those interviewed report feeling stigma and embarrassment…

A disease found in dogs where abnormally thick mucus accumulates in the gallbladder — called a mucocele — is characterized by altered levels and function of the CFTR protein that’s also faulty in cystic fibrosis (CF) patients, according to recent research. In contrast to the disease in humans, which…

Lung transplant rates among people with cystic fibrosis (CF) in the U.S. have declined dramatically since the approval of Trikafta (elexacaftor/tezacaftor/ivacaftor), a study found. However, almost half of patients who received transplants in recent years were on Trikafta before their procedures. Moreover, a notable proportion of CF patients…

Nearly two-thirds of cystic fibrosis (CF) patients in a study showed signs of type 2 inflammation, which was associated with worse lung function, more infections, and a higher risk of death. This form of inflammation, most commonly linked to allergic conditions, was reduced somewhat after treatment with CFTR…