Lindsey Shapiro, PhD,  science writer—

Researchers have uncovered a mechanism by which Pseudomonas aeruginosa and Aspergillus fumigatus — two common infection-causing microbes in the lungs of people with cystic fibrosis (CF) — are able to…

Families in the U.S. living with cystic fibrosis (CF) who’ve been affected by food insecurity feel that financial constraints imposed by the disease contribute to the problem and that government support programs are insufficient, interviews with patients and caregivers suggest. Those interviewed report feeling stigma and embarrassment…

A disease found in dogs where abnormally thick mucus accumulates in the gallbladder — called a mucocele — is characterized by altered levels and function of the CFTR protein that’s also faulty in cystic fibrosis (CF) patients, according to recent research. In contrast to the disease in humans, which…

Lung transplant rates among people with cystic fibrosis (CF) in the U.S. have declined dramatically since the approval of Trikafta (elexacaftor/tezacaftor/ivacaftor), a study found. However, almost half of patients who received transplants in recent years were on Trikafta before their procedures. Moreover, a notable proportion of CF patients…

Nearly two-thirds of cystic fibrosis (CF) patients in a study showed signs of type 2 inflammation, which was associated with worse lung function, more infections, and a higher risk of death. This form of inflammation, most commonly linked to allergic conditions, was reduced somewhat after treatment with CFTR…

Additional mutations in the SLC26A9 gene among cystic fibrosis (CF) patients with two copies of F508del — the most common CF-causing mutation in the CFTR gene — were associated with more rapidly declining lung function. These findings from a study further buttress the idea that variation in genes other…

A lung-targeted gene-editing therapy designed using technology from ReCode Therapeutics was able to successfully correct a disease-causing CFTR gene mutation in lung cells derived from cystic fibrosis (CF) patients, according to a recent proof-of-concept study. The therapy, developed using ReCode’s Selective Organ Targeting (SORT) lipid nanoparticles (LNPs), was…

Exposure in utero to the cystic fibrosis (CF) medication Trikafta (elexacaftor/tezacaftor/ivacaftor) didn’t appear to negatively affect organ development in fetal rats whose mothers were given it, but it did change the activity of some genes, a study finds. While the functional impacts of the changes remain to be…

A lung transplant can be lifesaving for children with cystic fibrosis (CF) admitted for respiratory failure to a pediatric intensive care unit (PICU). Only 35% of these young patients went on to be discharged without a transplant, according to an analysis of children with CF treated at a French…

Researchers have developed a device that could improve gene therapy delivery to the lungs for people with genetic conditions such as cystic fibrosis (CF). In a series of preclinical experiments, the research team showed that its device could deliver a therapeutic payload to cells better than a standard inhaler…