Marisa Wexler, MS,  senior science writer—

Boehringer Ingelheim has launched a Phase 1/2 clinical trial of BI 3720931, an inhaled gene therapy designed to treat cystic fibrosis (CF). The first-in-human trial, dubbed LENTICLAIR 1 (NCT06515002), is expected to enroll about 36 adults with CF who are not eligible for treatment with CFTR…

Young children with cystic fibrosis (CF) have less mature gut bacterial growth over time than do their typically developing peers, according to a new U.S. study. “Our findings demonstrate that the gut microbiota of infants with CF fails to undergo typical developmental maturation, instead remaining entrenched in a transitional-like…

In cystic fibrosis (CF), certain immune cells show signs of dysfunction very early in life, according to a new study that used an animal model as well as blood samples from young children with CF. Researchers think immune cell deficiencies may influence the cycles of infection and inflammation that…

Registration is now open for BreatheCon 2025, an annual online event hosted by the Cystic Fibrosis Foundation that aims to foster connections between adults with cystic fibrosis (CF). This year’s BreatheCon will take place Feb. 7-8. Registration and additional information about the virtual event is available on the…

A new triple-combination CFTR modulator therapy — vanzacaftor, tezacaftor, and deutivacaftor — has been approved by the U.S. Food and Drug Administration (FDA). The therapy, which developer Vertex Pharmaceuticals will market under the name Alyftrek, is indicated for cystic fibrosis (CF) in patients 6 and older who carry…

Infection with an airway bacterium called Haemophilus influenzae isn’t linked with worse lung health outcomes among adults with cystic fibrosis (CF), a study suggests. “Our study is the first to specifically dissect the natural history and consequences of H. influenzae infection in adult [people with] CF,” the researchers wrote. The…

A young man with cystic fibrosis (CF) successfully underwent a heart transplant, according to a first-of-its kind report described by researchers, who said the man’s heart issues arose as a rare complication of CF itself. The patient’s experience was described in the paper, “Isolated heart transplantation…

The Cystic Fibrosis Foundation is investing up to $15 million in Recode Therapeutics to help spur the development of new gene-editing medicines for people with cystic fibrosis (CF) who don’t have effective treatment options. “We are grateful to the CF Foundation for their ongoing support of our…

A Phase 1/2 clinical trial testing the inhaled gene therapy SP-101 in adults with cystic fibrosis (CF) has begun dosing, and is still recruiting participants, according to its developer Spirovant Sciences. The trial, called SAAVe (NCT06526923), aims to enroll 15 CF patients, ages 18 to 65. To…

Researchers have created a new technology to measure the thickness of mucus in the airways, which could aid in monitoring for cystic fibrosis (CF) and other diseases that affect the lungs. The team, led by scientists at Vanderbilt University in Tennessee, described the technology in the study, “…