Steve Bryson, PhD,  science writer—

People with cystic fibrosis (CF) experience a more severe disease course when they continue to have a small hole between the heart’s upper chambers that fails to close naturally after birth, a study suggests. The hole, called patent foramen ovale (PFO), in CF patients was linked to more…

More gastroenterologists with expertise in cystic fibrosis (CF) are needed alongside registered dietitians to provide comprehensive patient care, a survey study has found. The survey of registered dietitians and gastroenterologists found the involvement of gastroenterologists in caring for CF patients varied widely across specialty centers, with barriers that included…

The immune system of people with cystic fibrosis (CF) might be impaired due to long-term persistent lung infections and inflammation, a study suggested. Using a new and noninvasive standardized test for immune function called TruCulture, scientists found a lesser release of certain immune signaling proteins in immune cells from…

The balance of acids and bases in the urine of people with cystic fibrosis (CF) reflects lung and pancreas function, and the response to treatment, a study finds. The findings support measuring the bicarbonate base in urine, which mirrors the levels of various acids, as a tool to clinically…

A Phase 1b study that’s evaluating the safety of RCT2100, ReCode Therapeutics‘ investigational genetic medicine for people with cystic fibrosis (CF), has dosed its first patient. The inhalation therapy is being developed for CF patients who don’t respond to CFTR modulator therapies. “The initiation of our Phase…

The Cystic Fibrosis Foundation has awarded $3 million to support a study of mental health among young children with cystic fibrosis (CF) to University at Buffalo (UB) researcher Beth A. Smith, MD, a psychiatrist whose work in this area has already helped to get new screening programs into…

An infant boy, who was first seen with recurrent infections and a failure to thrive, was diagnosed with cystic fibrosis (CF) caused by a rare genetic mutation, a case study reports. “This case underscores the importance of considering CF even when classic symptoms are absent, as genetic mutation can…

SARS-CoV-2, the virus that causes COVID-19, appears to induce the loss of CFTR protein in a cell-based airway model, replicating the inflammatory state seen in the lungs of people with cystic fibrosis (CF), a study suggested. Treating cells with cardiac glycosides, a class of medicines that block the virus…

Cystic Fibrosis Foundation (CFF) grants will help fund four programs that support the well-being of people with cystic fibrosis (CF). The awards, given through the foundation’s ninth annual Impact Grants program, provide up to $10,000 to individuals and nonprofit organizations in the CF community. Since the program started…

CFTR correctors, such as elexacaftor, a component of the cystic fibrosis (CF) therapy Trikafta, may improve lung function through enhanced potassium flow via a protein channel called BKCa, a study has found. Potassium flow via BKCa is known to support the hydration of lung surfaces, similar to CFTR,…