AzurRx BioPharma, in partnership with Mayoly Spindler, announced that a recent Phase 2a clinical trial testing MS1819-SD as a potential treatment for exocrine pancreatic insufficiency (EPI) achieved its goals, namely a statistically significant improvement in fat absorption. EPI, often caused by cystic fibrosis, is a disease resulting from…
Sound Pharmaceuticals (SPI) will present data on the incidence and severity of ototoxicity in cystic fibrosis (CF) patients who received tobramycin for the treatment of acute pulmonary exacerbations. The presentation, which was accepted as a late-breaking abstract, will be given at the upcoming North American Cystic Fibrosis…
Biopharma Vivus recently supported the Dallas and Fort Worth chapters of the Cystic Fibrosis Foundation (CFF) in their CF Climb fundraising event at AT&T Stadium in Arlington, Texas, providing both sponsorship and employee participation. The company’s backing corresponded with its launch of Pancreaze (pancrelipase), approved…
Inhaled nitric oxide, AIT Therapeutics’ therapy candidate, was shown to have significant antibacterial activity against the bacterium Mycobacterium abscessus (M. abscessus), which often infects the airways of patients with cystic fibrosis. AIT announced the results of a laboratory study in a poster presentation titled, “High-dose…
A record 5,000 people from dozens of countries will gather next month in Denver for the 32nd Annual North American Cystic Fibrosis Conference (NACFC) — the world’s largest event focused on cystic fibrosis (CF) research and care. The Oct. 18-20 event at Denver’s Colorado Convention Center features 24 symposium sessions, 31…
Consuming dietary flavonoids — compounds naturally found in fruits, vegetables, chocolate, and beverages like wine and tea — may be associated with changes in gut bacteria that potentially affect the body’s metabolism, immune function, and inflammation in patients with cystic fibrosis (CF), a small…
The U.S. Food and Drug Administration gave positive feedback to the design of AmpliPhi Biosciences’ two proposed clinical trials of its Pseudomonas aeruginosa-targeting treatment candidate AB-PA01, the company announced in a press release. P. aeruginosa is the major cause of lung infections in cystic fibrosis patients.
A new electronic nose, called Aeonose, was seen to be a feasible, accurate and easy-to-use diagnostic test for cystic fibrosis (CF) in children and adolescents, a small pilot study shows. The research “Feasibility and diagnostic accuracy of an…
Blocking superoxide dismutase, the enzyme that responds to stress, in Pseudomonas aeruginosa bacteria improves antibiotics’ efficacy, a Canadian study reported. The study, “Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa,” was published in Proceedings of the National Academy of Sciences (PNAS). “We identified a new function important…
Cystic fibrosis patients who failed to show early improvements in lung function while being treated with Orkambi (lumacaftor/ivacaftor) still experienced fewer pulmonary exacerbations than those given a placebo in Phase 3 studies, a pooled analysis of those trials reports. Clinicians should consider the totality of outcomes when examining the…
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