Author Archives: Jose Marques Lopes PhD

Translate Bio Prioritizes Development of CF Therapy MRT5005, Other Lung Disease Candidates

Translate Bio is going to focus on the development of potential therapies to treat pulmonary diseases, including its lead candidate, MRT5005, targeting the underlying cause of cystic fibrosis (CF), the company announced. MRT5005 is designed to restore the levels of working cystic fibrosis transmembrane conductance regulator (CFTR) protein and reverse…

Hypertonic Saline Activates Neurons that Contribute to Airway Surface Liquid Production in CF, Study Suggests

Stimulation of neurons accounts for approximately half of the beneficial production of airway surface liquid (ASL) induced by hypertonic saline (HTS), a therapeutic agent used for cystic fibrosis (CF) treatment, according to research. The study, “Nebulized hypertonic saline triggers nervous system-mediated active liquid secretion in cystic fibrosis swine…


Featured Column

How to Ask for and Offer Help

A banner for Kate Delany's "Breathe and Believe" column that depicts a pair of lungs with flowers blossoming from them.
In times of need, we may not know how to ask for help or offer it to others. Columnist Kate Delany shares helpful tips on how to do it.

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