News

CF Patients Being Recruited for Phase 1 Study of Oral CFTR Amplifier

Proteostasis Therapeutics  announced it is now enrolling cystic fibrosis patients and healthy adults in two Phase 1 clinical trials evaluating its lead drug candidate PTI-428. PTI-428 is an oral amplifier of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Amplifiers are CFTR modulators that selectively increase the amount of an…

Production of CF Therapy Candidate AB569 for Clinical Trials to Begin

Arch Biopartners and  Catalent Inhalation, a division of Catalent Pharma Solutions, have entered agreements to start manufacturing AB569 for human trials in patients with chronic and antibiotic resistant bacterial lung infections. Representing a large part of the group affected, patients with cystic fibrosis  (CF) stand to benefit most. AB569, invented by Daniel Hassett,…

New 4-D Scanner Able to Peer Inside Lungs and Visualize Changes Caused by Cystic Fibrosis

New four-dimensional computed tomography (4DCT) for lung scans, developed by Professor Andreas Fouras at Monash University, offers the potential to revolutionize treatment for the millions of patients worldwide with lung diseases like cystic fibrosis. The 4DxV X-ray imaging technology, developed and commercialized by Professor Fouras’ technology company 4Dx, provides a state-of-the-art, noninvasive…

‘Sheer Stress’ Could Make Bacteria in Cystic Fibrosis Less Virulent

A recent study from Belgium showed that a common bacterium found in the lungs of people with cystic fibrosis (CF) might be converted to a less dangerous form, and could possibly aid in the development of treatments for the disease. The research report, “Effect of Shear Stress on Pseudomonas aeruginosa Isolated…

Surgery to Correct Spine Deformities in CF Could Produce Good Results with Adequate Care, Case Review Suggests

Spine deformities that are sometimes seen in cystic fibrosis (CF) may be adequately corrected with minimal risk through multidisciplinary care during surgery and meticulous surgical techniques, as reported by a case study reviewed in the article “Scoliosis Surgery in Cystic Fibrosis: Surgical Considerations and the Multidisciplinary Approach of a Rare Case.”