News

Kaftrio and Symkevi — marketed in the U.S. as Trikafta and Symdeko, respectively — may be effective in treating people with cystic fibrosis (CF) caused by rare mutations, according to a new study from the U.K. Both treatments were found to improve lung function and to ease…

Bacteria called Streptococcus parasanguinis may help inhibit the harmful effects of a Pseudomonas aeruginosa infection in the lungs of cystic fibrosis (CF) patients by modulating inflammation and increasing production of a metabolite called nitrite, recent preclinical research suggests. Previous research has linked these beneficial, or commensal, bacteria to…

A new study called ENHANCE is seeking to better understand the current effect of cystic fibrosis (CF) in young children. “There is so much to learn about the changes that are happening in children with CF, we are really excited about this new study,” Paul McNally, MD, a professor…

Treatment with Kaftrio eased gastrointestinal symptoms in people with cystic fibrosis (CF), ages 12 and older, according to a real-world study in the U.K and Ireland. The treatment’s maximum effect was achieved after two months and included a decline in gut inflammation. The study, “Reduction in abdominal…

More resources are needed to help identify and address education-related concerns among pediatric cystic fibrosis (CF) patients, a recent survey of care teams at CF centers in the U.S. shows. While the teams reported they were often involved in some education support — such as filling out forms or…

All the cystic fibrosis (CF) patients participating in the Phase 2 portion of a clinical trial have been dosed with BX004, an inhaled virus-based therapy for chronic Pseudomonas aeruginosa bacterial infections of the lungs. Data from the first part of the Phase 1b/2a study (NCT05010577) showed the…

Journaling — writing thoughts and feelings to understand them more clearly — improved the mental health of adolescents with cystic fibrosis, results from a feasibility study reveal. All teens with cystic fibrosis (CF) who completed post-therapy surveys said journaling helped them express their feelings and recommended others with CF…

Researchers have developed new synthetic molecules that can transport chloride salts across cell membranes, which showed promise for restoring normal mucus production in a cell model of cystic fibrosis (CF), a new study shows. “One day, [these molecules] could be leveraged into a drug that treats cystic fibrosis,” Bing…

More than half of the infections caused by the Burkholderia cepacia complex (BCC), a bacteria known to cause serious complications in people with cystic fibrosis (CF), were successfully eradicated, a 20-year study reported. Despite some CF patients testing negative following initial treatment for more than two years, however, subsequent…

Freezing and thawing breast milk negatively affected how nutrients are digested under lab conditions mimicking the gastrointestinal environment of an infant with cystic fibrosis (CF), scientists report. The addition of pancreatic enzyme replacement therapy (PERT) at sufficient doses was able to restore more normal fat breakdown under CF…