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A high burden of infection-causing bacteria persisted in the lungs of people with cystic fibrosis (CF) who were treated with Trikafta (elexacaftor/tezacaftor/ivacaftor) in a recent study, despite an increase in the overall diversity of microbes and improvements in lung function being seen. The changing dynamics of this microbial…

Various social and environmental factors in different locations across the U.S. influenced a decline in lung function among adolescents and young adults with cystic fibrosis (CF), a large-scale analysis demonstrated. CF patients with early lung function decline tended to live in areas with more social-environmental adversity, such as higher…

Treatment with the inhaled antibiotic aztreonam can stabilize lung function in people with cystic fibrosis (CF) who have chronic infections of the bacterium Pseudomonas aeruginosa. That’s according to “Inhaled aztreonam lysine in the management of Pseudomonas aeruginosa in patients with cystic fibrosis: real-life effectiveness,”…

In people with cystic fibrosis (CF), six months of treatment with Kaftrio — sold as Trikafta in the U.S. — significantly reduced the blood levels of molecules called chemokines that are involved in inflammation, new research shows. Noting that “exaggerated inflammation is a major driver of disease progression…

The total cost of managing cystic fibrosis (CF) — healthcare costs, patient and caregiver costs, as well as costs to society — varied widely per patient per year in a review of published studies. Most studies only reported costs to the healthcare system, such as hospitalizations and healthcare visits,…

At-home telemonitoring of lung function in children with cystic fibrosis (CF) can detect the early onset of pulmonary exacerbations, or a sudden worsening of lung symptoms, and may help in determining the likelihood of a child’s response to treatment, a study reported. Its researchers proposed thresholds for lung function…

Fas, a protein that triggers programmed cell death, was identified as a potential urinary biomarker for kidney injury associated with certain antibiotics used to treat lung infections in people with cystic fibrosis (CF), a new study shows. To identify Fas as a biomarker, researchers used a three-dimensional cell-based system…

African American cystic fibrosis (CF) patients described, in a new interview study, the lifetime of challenges they face in living with a disease often misconstrued as one that only affects white people. A lack of representation and cultural insensitivity from healthcare teams, mental health concerns, and an inability to…

Cough and sputum symptoms in adults with cystic fibrosis (CF), as assessed by the Cough and Sputum Assessment Questionnaire (CASA-Q), were significantly linked to impaired quality of life, according to a pilot study. Worse cough and sputum symptoms occurred more often in women, those with severe shortness of breath…

Blood levels of an indicator of diabetes, glycated hemoglobin (HbA1c), fell within the first year that cystic fibrosis (CF) patients were treated with Kaftrio, the triple combination therapy marketed as Trikafta in North America, according to a study of patients in Denmark. But among those with CF-related…