ReCode Therapeutics Raises $80M to Boost Development of CF Therapies

ReCode Therapeutics Raises $80M to Boost Development of CF Therapies
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ReCode Therapeutics has raised $80 million in Series A financing to support the preclinical development of its lead targeted RNA therapy for cystic fibrosis (CF).

The funding also will be used to support the development of RNA therapies for primary ciliary dyskinesia (PCD), a hereditary condition that impairs the function of lung cilia — the fingerlike projections in the airways — leading to chronic respiratory infections.

“Our preclinical studies demonstrate that our targeted RNA therapies have great potential for the treatment of life-threatening pulmonary diseases,” David Lockhart, PhD, president and CEO of ReCode Therapeutics, said in a press release.

The RNA therapy being developed for CF is called tRNA NanoCorrector. It uses an RNA molecule called transfer RNA (tRNA), which plays a role in the process of protein production.

Specifically, the tRNA NanoCorrector was designed to recognize mutations that introduce a premature stop sequence into the making of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. (These mutations are the cause of CF.) This premature stop sign results in the production of a shortened version of the CFTR protein, which is then degraded by the cell.

The NanoCorrector substitutes the stop sequence for a “go” sequence, so that the full CFTR protein is produced.

The new financing also will support the development of ReCode’s non-viral lipid nanoparticle delivery platform (LNP), which uses non-viral fat (lipid) particles to deliver RNA therapies and other types of gene-editing tools with precision to targeted organs.

“I’m especially grateful to ReCode’s founders, professors Daniel Siegwart, PhD, and Philip Thomas, PhD, at the University of Texas Southwestern Medical Center, and Professor Emeritus Arthur Johnson from Texas A&M University whose foundational research played an instrumental role in cultivating both the LNP delivery platform and the CF therapeutic program,” Lockhart said.

“We are grateful to the Cystic Fibrosis Foundation, whose financial support has allowed us to play a pivotal role in understanding the pathogenesis of CF and led to the development of a novel therapeutic approach for correcting nonsense mutations for this severe disease,” Lockhart added.

ReCode hopes to advance its RNA targeted therapies into clinical trials for CF and PCD. The company plans to file an investigational new drug application (IND) for both clinical programs in 2021.

“We are pleased to close this financing round with world-class investors who believe in the bold vision of our new company. With these additional resources, we’re focused on advancing our preclinical programs into the clinic over the next two years,” Lockhart said.

The investment in Series A financing was co-led by OrbiMed Advisors and Colt Ventures, and had the support of multiple investors, including MPM Capital, Vida Ventures, Hunt Technology Ventures, and Osage University Partners.

“We believe that ReCode has an exceptional opportunity to advance its targeted RNA therapies and LNP delivery platform to address the critical needs of patients living with devastating genetic respiratory diseases,” said Peter Thompson, MD, partner at OrbiMed.

“The board looks forward to supporting ReCode’s evolution as it moves these compelling therapies into the clinic,” Thompson said.

Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Department of Microbiology & Immunology, Columbia University, New York.
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Patrícia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.

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Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Department of Microbiology & Immunology, Columbia University, New York.
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