Ana Pamplona, PhD,  —

A new study of children with cystic fibrosis found that co-infection with methicillin-resistant bacteria may be associated with increased pulmonary morbidity, especially in children with repeat hospitalizations. The retrospective study, conducted at a U.S. pediatric medical center with high rates of methicillin-resistant respiratory infections, is titled “Clinical characteristics and…

New complexes of nickel (II) with imidazole derivatives were evaluated as potential treatment for P. aeruginosa biofilm eradication in cystic fibrosis. The study, titled “The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis” was published…

A new cystic fibrosis study, showing a high-resolution picture of the fungal microbiome of cystic fibrosis patients’ lungs, has identified a genetic basis for pathogen adaptation in a fungus exposed to bacteria. The study, entitled “Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of…

The U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation for AB569 from Arch Biopartners Inc. as a treatment for Pseudomonas aeruginosa (P. aeruginosa) pulmonary infections in patients with cystic fibrosis. The Orphan Drug Designation is a crucial step for the development of new medicines for…

A new study entitled “Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium,” published in the PLOS One journal, highlights the potentially positive impact of intravenous antibiotic colistimethate sodium in the proportion of Pseudomonadales relative to other Gram-negative…

A new study entitled “Respiratory microbiota resistance and resilience to pulmonary exacerbation and subsequent antimicrobial intervention,” published in The International Society for Microbial Ecology Journal, investigated how bacterial communities in the lung change over time in relation to the disease state and progression of…

A new study entitled “Vitamin D and Chronic Lung Colonization in Pediatric and Young Adult Cystic Fibrosis Patients” published in the Spanish-language journal Nutrición Hospitalaria, investigated vitamin D levels in the body and its association with chronic lung colonization. The study showed that vitamin D supplements did not improve…

A new study revealed that the cystic fibrosis transmembrane conductance regulator (CFTR) plays an important role in regulating the intestinal inflammatory responses. The study, entitled “CFTR Knockdown induces pro inflammatory changes in intestinal epithelial cells,” was published in the Journal of Inflammation…

A new study revealed that treating P. aeruginosa biofilms with the antibiotic tobramycin together with mannitol — two well-known therapies in treating lung infections in CF — did not reduce overall bacterial load. The study entitled “Mannitol Does Not Enhance Tobramycin Killing of Pseudomonas aeruginosa in a Cystic Fibrosis Model System…

New research has revealed potential, new strategies to fight against P. aeruginosa infection and improve both survival and quality of life in patients with cystic fibrosis. The study, entitled “Normal and Cystic Fibrosis Human Bronchial Epithelial Cells Infected with Pseudomonas aeruginosa Exhibit Distinct Gene Activation Patterns” was published in the …