Andrea Lobo, PhD,  science writer—

A defect in an anti-inflammatory pathway called IL-37-SIGIRR contributes to the hyperinflammation seen in lung epithelial cells in patients with cystic fibrosis (CF), a new study suggests. The study shows, for the first time, that a mutated form of the single immunoglobulin interleukin-1 receptor (IL-1R)-related molecule (SIGIRR), named delta…

The clinical outcome of lung infection with Mycobacterium abscessus (M. abscessus) in cystic fibrosis (CF) patients is associated with genetic differences in the bacterium strains, according to a recent study. The study identified virulence factors related to disease severity, and sheds light on the development of novel and more effective…