Margarida Maia, PhD,  science writer—

Adding the experimental treatment CMTX-101 to standard antibiotics reduced the number of Pseudomonas aeruginosa — a type of bacteria often involved in serious infections — in the lungs of people with cystic fibrosis (CF), while also being safe and well tolerated. These are interim findings from 21 patients…

While most adults with cystic fibrosis (CF) view their health as very good or excellent while on Kalydeco (ivacaftor) or Trikafta (elexacaftor/tezacaftor/ivacaftor) — both approved CFTR modulator therapies for CF — about 1 in 7 still report their health as fair or poor, a survey study…

Using inhaled antibiotics can help control the growth of certain bacteria in the lungs, but it may increase the risk of fungal infections with Aspergillus fumigatus in people with cystic fibrosis (CF), according to a study. The study, “Association between inhaled antibiotic use and treatment-emergent organisms among Canadian people with cystic fibrosis,”…

In young children with cystic fibrosis (CF), infections with methicillin-resistant Staphylococcus aureus (MRSA) are linked to more antibiotic use, worse lung function, and more lung damage by early school age, according to a study led by researchers in Brazil. Because infections with MRSA appear to indicate more severe disease…

Home-based spirometry — a test to measure how well the lungs are working — provides results that are almost as reliable as those taken in a hospital, and such testing could help people with cystic fibrosis (CF) monitor their condition without as many visits to the doctor, a study…

Regular exercise improves fitness in adults with cystic fibrosis (CF), and treatment with Kaftrio — a combination of elexacaftor, tezacaftor, and ivacaftor that’s marketed as Trikafta in the U.S. — may help patients engage more in higher-intensity physical activity, a German study suggests. The study, “Effects of…

People with diabetes related to cystic fibrosis (CF) who had better long-term sugar control were more fit, a study found, suggesting that keeping blood sugar within normal limits may help improve the ability to exercise. The study, “The association between dysglycaemia and exercise capacity in cystic fibrosis,” was…

Kaftrio (elexacaftor/tezacaftor/ivacaftor), branded as Trikafta in the U.S., may help clear the nasal passages and surrounding air-filled cavities, known as sinuses, in children and adolescents with cystic fibrosis (CF), according to a real-world study from France. In the MODUL-CF study (NCT04301856), which involved 391 children and adolescents…

Pregnancy does not negatively impact survival or lung function in women with cystic fibrosis (CF) and, in fact, may be associated with a lower risk of death, according to a U.S. study that compared CF women who had been pregnant with those who had never been pregnant. No significant…

Registration is now open for ResearchCon 2025, a free event the Cystic Fibrosis Foundation assembles each year for researchers, doctors, and patients to share and discuss the latest advances in research and clinical care in cystic fibrosis (CF). This virtual event, set online for May 6, provides…