Margarida Maia, PhD, science writer —

Certain markers of inflammation found deep in the lungs of children with cystic fibrosis (CF) can help predict how bronchiectasis will worsen over time, offering insights for better treatment and care, a study suggests. Among other markers, higher levels of interleukin-8 (IL-8), a signaling…

Between 2011 and 2021, improving lung function and better survival rates were consistently seen among people with cystic fibrosis (CF) in Europe, particularly in wealthier countries and with the introduction of new treatments, according to a study that tracked more than 45,000 CF patients across the continent over the…

The antibiotic arenicin may be effective at killing resistant Mycobacterium abscessus, a type of bacteria that can cause serious infections in people with cystic fibrosis (CF), according to a study in cells. Given alone or in combination with conventional antibiotics,…

Staying physically active, especially engaging in more vigorous exercise regularly, is important for lung health and life quality in adolescents and adults with cystic fibrosis (CF), a study reports. Better lung function and exercise capacity were key factors in a patient’s overall quality of life, the researchers found, adding…

No significant link was seen between an increase in body mass index (BMI), a measure of body fat based on weight and height, and higher blood fats and vitamin levels in people with cystic fibrosis (CF) being treated with Trikafta (elexacaftor/tezacaftor/ivacaftor), a study in adult and pediatric patients…

Discontinuing dornase alfa while on Trikafta (elexacaftor/tezacaftor/ivacaftor) could cut down on prescription costs by more than $1 billion each year in the U.S., according to estimates based on data from a randomized controlled trial. The savings would not compromise health, at least not for the short term, as people…

Two imaging techniques, called elastography and spectroscopy, can detect liver stiffness (hardness) and the buildup of fat in the liver in children with cystic fibrosis (CF) — particularly among those with CF-related liver disease — a study found. Importantly, because elastography and spectroscopy are noninvasive, these scans may offer…

Sail Biomedicines’ experimental programmable RNA technology, called Endless RNA or eRNA, appears to result in long-lasting production of the protein that is missing or faulty in people with cystic fibrosis (CF), according to research funded by the CF Foundation. Producing the protein over an extended period of…

Taking CFTR modulators as a child may make boys and girls with cystic fibrosis (CF) grow about a third of an inch taller by the time they turn 18, according to a large study of data from the CF Foundation patient registry. Researchers also observed that being taller…

Structural improvements in the airways and sinuses of adults with cystic fibrosis (CF) were seen on CT scans after a year on Kaftrio, and occurred alongside reductions in CF symptoms and gains in measures of lung function, according to an Italian study. “Imaging findings on CT during…