Margarida Maia, PhD,  science writer—

Children with cystic fibrosis (CF) who are being treated with Symdeko (ivacaftor/tezacaftor) or Orkambi (ivacaftor/lumacaftor) experience few to no symptoms of chronic rhinosinusitis and maintain a normal sense of smell, a study in Denmark found. Although small, the study suggests that not only Trikafta, a triple…

CFTR modulators may help control glucose (sugar) levels in the blood of people with cystic fibrosis (CF), according to researchers in Israel, who called for regular oral glucose tolerance testing to adjust insulin dosing in diabetes and keep glucose from dropping too low. The study, “Long-Term therapy with…

Low doses of ETD001, an inhaled medication being develop by Enterprise Therapeutics to treat cystic fibrosis (CF), acted for longer than expected and helped to clear mucus from the airways of sheep in a study. Equivalent doses also were well tolerated in an earlier Phase…

ARCT-032, a messenger RNA inhalation treatment being developed by Arcturus Therapeutics to restore a working protein in the lungs of cystic fibrosis (CF) patients, showed safety in healthy adults and early signs of potential efficacy in a small group of patients taking part in a Phase 1/1b…

Women with cystic fibrosis (CF) who have been pregnant three or more times are more likely to experience a greater decline in lung function and, when 30 or older, to give birth to preterm babies or babies with complications, a study has found. Lung function appeared to decline more…

Certain neutrophils, a type of immune cell that’s released quickly into the bloodstream to help fight off infections, appear to be linked to better lung function in some people with cystic fibrosis (CF), a study finds. The presence or abundance in the blood of certain other immune cells and…

One year of treatment with Kaftrio (elexacaftor/tezacaftor/ivacaftor), branded Trikafta in the U.S., helped people with cystic fibrosis (CF) gain exercise capacity, particularly those who saw changes in weight and lung function, according to a study out of Denmark. While there was a significant increase in the highest amount…

Parents of infants and toddlers with cystic fibrosis (CF) often see their children as weighing less than they actually do, and feel they eat more slowly and enjoy food less than healthy children, according to a small U.S. study. Using questionnaires like the Baby Eating Behavior Questionnaire (BEBQ), a…

About every fourth member of the cystic fibrosis (CF) community feels they’re not provided clear information about cross infection and infection prevention and control, according to a survey conducted in 13 countries. Many survey respondents, mostly girls and women, said they’d wash and disinfect their nebulizers more frequently if…

People with cystic fibrosis (CF) who carry two disease-causing F508del mutations and those who have had no prior treatment with CFTR modulators are up to five times more likely to see greater improvement of sinonasal symptoms after starting highly effective modulator treatment, a study found. An improvement of…