Marisa Wexler, MS,  senior science writer—

Researchers at The Rockefeller University in New York City have determined how two medications used to treat cystic fibrosis (CF), lumacaftor and tezacaftor, interact with the CFTR protein. The results suggest that these medicines bind to the protein — usually impaired or missing in people with CF — and…

The Cystic Fibrosis Foundation has announced an investment in SalioGen Therapeutics to support the company’s preclinical research toward  developing a new gene therapy for cystic fibrosis (CF). SalioGen is working to advance a novel type of gene therapy, called Gene Coding, which is accomplished using the company’s…

EnBiotix has raised $11 million in financing that will help fund clinical testing of ColiFin (inhaled colistimethate sodium) and murepavadin, two antibiotics that may be useful for controlling lung infections in people with cystic fibrosis (CF). Some of the funding was from the Cystic Fibrosis Foundation,…

An endoscopic sinus surgery (ESS) is best performed within a few years of a lung transplant in cystic fibrosis (CF) patients, as longer wait times are associated with worse lung function and more antibiotic use, a small study reported. This finding could be relevant because “lung transplant recipients with CF…

People in the U.K. at highest risk of becoming seriously ill from COVID-19 — including those with cystic fibrosis (CF) — starting on Dec. 16 will have access to medications that can lessen the risk of severe disease through the country’s National Health Service (NHS). Two medications will be available:…

Blocking the protein SGLT1, which regulates glucose uptake in cells, may be a useful in treating cystic fibrosis (CF), according to research done in a cell model of the disease. SGLT1 inhibitors are likely less effective that currently approved modulators for patients with eligible mutations, its scientists noted, but…

Many women with cystic fibrosis (CF) wish to have biological children, but they often lack proper education and resources about fertility preservation, a U.S. study found. The study, “Fertility preservation in women with cystic fibrosis pre-lung transplantation: A mixed methods study,” was published in the Journal…

Epithelial cells collected from the nasal passages and grown in the lab under a specialized protocol could be a useful model for studying the molecular underpinnings of cystic fibrosis (CF) and testing potential treatments, a study reported. The study, “Correlating genotype with phenotype using CFTR-mediated whole-cell…

People with cystic fibrosis (CF) who score highly on measures of self-compassion tend also to report higher quality of life, a study found. “The current findings suggest that psychological interventions which increase self-compassion could be beneficial for enhancing better mental health and quality of life for adults with CF,”…

Large-scale clinical trials and other research are “urgently required” to determine the best ways to manage the growing number of infections with nontuberculous mycobacteria — known as NTM — among children with cystic fibrosis (CF). That’s the argument made by a team of scientists in the U.K., in the…