Marisa Wexler, MS,  senior science writer—

A lipid nanoparticle designed to deliver genetic therapy to lung cells could be used as a platform to treat lung-related diseases like cystic fibrosis (CF), a mouse study found. Researchers developed a way to identify lipid nanoparticles — fatty molecules that help deliver genetic material to cells — that…

A persistently stuffy nose is a big concern for people with cystic fibrosis (CF) who have chronic nose inflammation, but loss of smell isn’t as significant a worry, according to a new study that used the SinoNasal Outcome Test (SNOT-22). “Nasal congestion and post-nasal discharge were top priorities reported…

In the years after Kalydeco (ivakaftor) became available, the use of pancreatic enzyme replacement therapy (PERT) fell among people with cystic fibrosis (CF) in the U.S. who were eligible for the therapy. That’s according to “Pancreatic enzyme prescription following ivacaftor licensing: A retrospective analysis…

Treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) significantly reduced rates of colonization with the bacterium Pseudomonas aeruginosa in adults with cystic fibrosis (CF) at a center in Kentucky. Trikafta also reduced the need for mucus-clearing medicines and antibiotics, according to the study “Impact of Elexacaftor/tezacaftor/ivacaftor on Respiratory Colonization…

Compounds secreted by Lactobacillus, a group of bacteria commonly used in probiotics, are able to impede the growth of Pseudomonas aeruginosa isolated from the lungs of people with cystic fibrosis (CF). That’s according to the study, “Cell-free supernatants from Lactobacillus strains exert antibacterial, antibiofilm, and antivirulence…

Intellia Therapeutics and ReCode Therapeutics are joining forces to develop new genomic medicines for people with cystic fibrosis (CF). The companies said initial research will focus on patients who have “limited or no treatment options available.” The ultimate goal is to create a new genomic medicine that…

The frequent use of aminoglycosides — a class of antibiotics commonly used to help treat lung infections in people with cystic fibrosis (CF) — has been linked to an increased risk of hearing problems in CF patients, starting in childhood, according to a new pediatric study in Belgium. The…

A new triple-combination CFTR modulator therapy for cystic fibrosis (CF) — vanzacaftor, tezacaftor and deutivacaftor — outperformed the approved therapy Trikafta (elexacaftor/tezacaftor/ivacaftor) at reducing sweat chloride levels in Phase 3 trials. The new “vanza triple” combo was similar to Trikafta at maintaining…

Enterprise Therapeutics has raised £26 million (nearly $33 million USD) in series B financing, which the company is planning to use to fund a Phase 2a clinical trial of EDT001, its experimental treatment for cystic fibrosis (CF). The upcoming trial is expected to enroll people with CF who…

Treatment with SPI-1005 in adults with cystic fibrosis (CF) appeared to lessen the risk of ear damage related to antibiotics use — widely prescribed for treating lung infections in CF patients — in a Phase 2 clinical trial. That’s according to new interim data from the STOP study…