Patrícia Silva, PhD, director of science content —

Galapagos dosed the first cystic fibrosis (CF) patient with GLPG2222, its novel CF corrector, in a Phase 2a clinical trial evaluating the drug as an add-on therapy to Kalydeco (ivacaftor) in CF patients harboring one F508del CFTR mutation and one gating mutation. The ALBATROSS Phase 2a clinical trial…

The U.S. Food and Drug Administration (FDA) has designated Concert Pharmaceuticals‘ next-generation therapy, CTP-656, an Orphan Drug to treat cystic fibrosis (CF). CTP-656 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that, according to the company’s website, was developed by applying deuterium chemistry to modify Kalydeco (ivacaftor).  Concert has said…

The Cystic Fibrosis Foundation has announced the recipients of its first Impact Grants, which support individuals or organizations that positively impact the cystic fibrosis (CF) community. The winners will each receive $10,000. “People with CF have the greatest insights about how to live with this disease,” Drucy Borowitz, MD, vice…

The first patients have been dosed in the Phase 2 clinical trial evaluating NovaBiotics‘ Lynovex (NM001, cysteamine) as an adjunct therapy for infectious exacerbations in cystic fibrosis (CF). CARE-CF (NCT03000348, NBTCS-02) is a randomized, double-blind, parallel group, and placebo-controlled study designed to investigate the optimal dose…

First Allied Securities has given the Cystic Fibrosis Foundation a $73,487 donation for research and programs dealing with the disease. Archie Manning, a retired National Football League quarterback, donated memorabilia that First Allied’s charity arm, First Philanthropy, auctioned for some of the donation. In the past seven years, First Philanthropy has…

Cystic Fibrosis Foundation Therapeutics (CFFT), the drug discovery arm of the Cystic Fibrosis Foundation (CFF), has awarded Aridis Pharmaceuticals a grant to help develop Panaecin (gallium citrate), the company’s development-stage treatment for bacterial lung infections. Panaecin is being evaluated in a Phase 2a clinical trial (GALLIUM-IP-13, NCT02354859) in…

Hubrecht Organoid Technology (HUB) and the Dutch health insurance companies CZ, Zilveren Kruis and Menzis plan to launch a €3 million ($3.1 million) validation trial to determine whether HUB’s organoid technology can be used to assess how cystic fibrosis (CF) patients might respond to new therapies. HUB’s technology is based…

Researchers at the University of Limerick, in Ireland, have developed a disposable percussion device, called SoloPEP, that works to remove mucus from the airways of people with cystic fibrosis (CF) so as to lessen their likelihood of infections, leading  to fewer doctor’s appointments, less antibiotic use, and shorter hospital stays. “SoloPEP…

A research team at Northwestern University has developed a flexible and wearable electronic device, which adheres to the skin, to measure sweat, monitor response to exercise, and detect the presence of certain biomarkers — all of which are relevant for conditions such as cystic fibrosis (CF). “Sweat is a rich, chemical…

Scientists at the University of Queensland, Australia, are focusing their efforts on what is one of world’s leading sources of antibiotic resistance — biofilm. Biofilms refer to the communities of bacteria and other microorganisms that adhere to surfaces in thin layers and secrete a protective coating that diminishes the effects of antibiotics. Biofilms are considered…