Steve Bryson, PhD,  science writer—

Some people with severe asthma, an inflammatory lung condition, carry variants of the CFTR gene that causes cystic fibrosis (CF), a genetic study found. These findings support the genetic assessment of severe asthma patients with CF-related symptoms, the scientists recommended. The study, “DNA Sequencing Analysis of…

Triple combination therapies, a mix of CFTR correctors and potentiators, significantly improve lung function, reduce sweat chloride, and enhance the quality of life for people with cystic fibrosis (CF), a meta-analysis of pooled results from multiple clinical trials shows. The meta-analysis, “Efficacy and Safety of Triple…

The first patient has been dosed in a Phase 1/2 clinical trial evaluating 4D-710, an investigational genetic medicine for adults with cystic fibrosis (CF), its maker, 4D Molecular Therapeutics (4DMT) has announced. “The dosing of the first patient in the 4D-710 Phase 1/2 clinical trial in cystic fibrosis…

A new online exercise and yoga program for children and adolescents living with cystic fibrosis (CF) is in development by Beam and CF Yogi, and will launch — with no costs to youth — in August on Beam’s virtual well-being platform. The program, created with the Johns…

Survival following lung transplant due to cystic fibrosis (CF) in children ages 10 and younger was similar to survival among older CF children with one key difference, a hospital study suggests. While recognizing and treating diabetes, infections, and other lung conditions early may prevent or slow lung disease progression,…

The COVID-19 pandemic markedly limited exercise training and related services provided at cystic fibrosis (CF) care centers in the U.K., but they largely continued through online offerings, a survey found. Most clinics adapted by expanding telehealth services to include online exercise classes, clinical monitoring, and consultations, responses showed, and many…

HIT-CF, a European Union-funded research project, is working to provide personalized disease-modifying treatments to cystic fibrosis (CF) patients with rare CFTR mutations who lack effective treatment options. “We hope that within five years, these patients will have new drugs,” Kors van der Ent, MD, PhD, professor in pediatric…

The bacterial composition within the airways of children with cystic fibrosis (CF) differs from those with primary ciliary dyskinesia (PCD), a disorder also characterized by mucus buildup and lung infections, a study reported. Its researchers, who followed children with either disease for about one year, found airway bacterial diversity…

Monocyte immune cells from bone marrow partially transplanted into a mouse model of cystic fibrosis (CF) improved survival and reduced inflammation, a study found. Meanwhile, transplanting monocytes from CF mice into healthy mice triggered CF-like symptoms and limited survival, suggesting that these defective immune cells may cause symptoms, the…

The Cystic Fibrosis Foundation has awarded funding to Feldan Therapeutics to develop the Feldan Shuttle, a technology designed to deliver medicines directly inside the epithelial cells that line the airways in people with cystic fibrosis (CF). Awarded as part of the foundation’s $500 million Path to…