Steve Bryson, PhD,  science writer—

A detailed analysis of lung tissue of cystic fibrosis (CF) patients found specific changes to the extracellular matrix (ECM), the three-dimensional network of molecules and proteins outside the cell that supports lung function, a study showed. Drivers of ECM breakdown may act as therapeutic targets or biomarkers to monitor…

ReCode Therapeutics’ investigational aerosolized RNA-based therapies for cystic fibrosis (CF) restored CFTR function, the defective protein in CF, in patient-derived lung cells. Delivered by the company’s selective organ targeting (SORT) lipid nanoparticle (LNP) platform, the therapy showed no signs of toxicity in epithelial cells that line the airways.

LungFit GO, inhaled nitric oxide (NO) that can be self-administered at home, was well tolerated and improved various quality of life measures, according to recent data from a pilot study that evaluated the experimental treatment in adults with or without cystic fibrosis (CF). The ongoing study involves people…

For the first time, bacteriophages — viruses that kill bacteria — eliminated an antibiotic-resistant mycobacterial lung infection in a man with advanced cystic fibrosis (CF) lung disease, a study reported. As a result, the patient was able to undergo a successful lung transplant after one year of bacteriophage treatment.

Cases of severe COVID-19 remained low during the first year of the pandemic in people in France with cystic fibrosis (CF), a study reported. Patients with severe lung disease or CF-related diabetes, as well as those who underwent a lung transplant, however, were at a higher risk of…

Some people with severe asthma, an inflammatory lung condition, carry variants of the CFTR gene that causes cystic fibrosis (CF), a genetic study found. These findings support the genetic assessment of severe asthma patients with CF-related symptoms, the scientists recommended. The study, “DNA Sequencing Analysis of…

Triple combination therapies, a mix of CFTR correctors and potentiators, significantly improve lung function, reduce sweat chloride, and enhance the quality of life for people with cystic fibrosis (CF), a meta-analysis of pooled results from multiple clinical trials shows. The meta-analysis, “Efficacy and Safety of Triple…

The first patient has been dosed in a Phase 1/2 clinical trial evaluating 4D-710, an investigational genetic medicine for adults with cystic fibrosis (CF), its maker, 4D Molecular Therapeutics (4DMT) has announced. “The dosing of the first patient in the 4D-710 Phase 1/2 clinical trial in cystic fibrosis…

A new online exercise and yoga program for children and adolescents living with cystic fibrosis (CF) is in development by Beam and CF Yogi, and will launch — with no costs to youth — in August on Beam’s virtual well-being platform. The program, created with the Johns…

Survival following lung transplant due to cystic fibrosis (CF) in children ages 10 and younger was similar to survival among older CF children with one key difference, a hospital study suggests. While recognizing and treating diabetes, infections, and other lung conditions early may prevent or slow lung disease progression,…