Vanda Pinto, PhD, science writer —

Clustering of the CFTR protein in lipid (fat)-rich platforms on the cell membrane, which can occur when the cell is under stress and increases the number of working CFTR proteins, is disrupted by cystic fibrosis (CF)-causing mutations, a recent study shows. CFTR modulators that are part of Trikafta were…

A cluster of Mycobacterium abscessus (M. abscessus), a difficult-to-treat bacteria that causes lung damage, particularly in people with cystic fibrosis (CF), was identified in the southeastern Florida, a recent study reported. According to its findings, patients who tested positive for a nontuberculous mycobacteria (NTM) infection, including M. abscessus, were…

In children with cystic fibrosis (CF), evidence of the bacteria Pseudomonas aeruginosa was associated with poorer lung function — based on predicted forced expiration volume in one second, FEV1% — while those testing positive for rhinovirus, which frequently causes the common cold, were more likely to have better…

Boehringer Ingelheim has taken legal steps giving it the lead role in further development of a long-lasting, inhalation gene therapy for cystic fibrosis (CF), called BI 3720931, that stems from a public-private research effort begun in 2018. The 2018 agreement brought together Boehringer, the U.K. Cystic Fibrosis…

Blacks and Hispanics with cystic fibrosis (CF) have worse lung function than white patients, according to a study from New York City. However, no differences were found among these groups of patients in several other parameters, including the number of visits to the doctor, treatments with antibiotics, and hospitalizations. The…

Nathan Perdue, the father of a 2-year-old boy with cystic fibrosis (CF), in collaboration with the Kentucky Derby Museum, is raffling off his limited-edition collection of bourbons to support the Cystic Fibrosis Foundation (CFF) and its efforts to cure this disease within his son’s lifetime. The collection includes…

Children with cystic fibrosis (CF) who gain less than 2.5 kg (or 5.5 lbs) per year between the ages of five and 10 are nine times more likely to develop cystic fibrosis-related diabetes (CFRD) in adolescence, a new study reports. The findings highlight the need to monitor closely…

Source water levels of a metal called molybdenum is a significant environmental risk factor for nontuberculous mycobacteria (NTM) infection among people in Colorado with cystic fibrosis (CF), a database study focused on that state reported. NTM infection, caused by Mycobacterium abscessus (M. abscessus), is a difficult-to-treat bacterial infection, and…

A new biomaterial made up of nanoparticles showed a potential to improve — by up to 100,000 times — the efficiency of tobramycin, an antibiotic used to treat cystic fibrosis (CF) patients with Pseudomonas aeruginosa infections. Tobramycin, carried within a nanostructured material, completely eradicated P. aeruginosa infection in a…

Long-term use of Orkambi (lumacaftor/ivacaftor), an approved cystic fibrosis (CF) treatment, is safe and effective for children between ages 2 and 5 with two copies of the disease-causing F508del mutation in the CFTR gene, a study reported. It draws on results from a Phase 3 open-label extension trial…