Antibiotic susceptibility tests that determine how people with lung infections will respond to antibiotics may work better if researchers grow the pathogenic bacteria in the lab along with other commensal bacteria found in the lungs, because it more accurately mimics their real environment, a recent study suggests. The reason for…
cystic fibrosis
The antibiotic-resistant bacterium Stenotrophomonas maltophilia, a dangerous bacteria for people with lung diseases such as cystic fibrosis (CF), is widely spread around the world, with most strains carrying virulence and resistance genes, a large genetic study shows. The study, “The phylogenetic landscape and nosocomial spread of…
Researchers identified a biochemical mechanism that regulates the thickness of mucus, and could serve as a target of new treatments for chronic respiratory illnesses that include cystic fibrosis (CF). The study, “Trefoil factors share a lectin activity that defines their role in mucus,” was published in the journal …
While the COVID-19 outbreak has turned Cystic Fibrosis Foundation (CFF) activities into online events, Cystic Fibrosis Awareness Month continues to move forward, and with an emphasis on patient stories and education. Observed each May, the month is set aside to raise support and awareness for cystic fibrosis (CF), an…
Calithera Biosciences announced plans to open by September a first clinical study of its oral investigational therapy CB-280 in people with cystic fibrosis (CF). The Phase 1b, dose-escalating trial (NCT04279769) in up to 32 adults with cystic fibrosis and chronic lung infections caused by Pseudomonas aeruginosa was…
A potential gene therapy for cystic fibrosis, KB407, is able to induce the expression of normal CFTR protein in cell models of CF, its developer, Krystal Biotech, reports. These data are in the poster, “In vitro Pharmacology of KB407, an HSV-1 based gene therapy vector,…
A man-made antibiotic able to fight drug-resistant bacteria in the lungs with minimal toxicity to a person’s cells may be a promising approach to eliminate lung infections, such as those caused by resistant Pseudomonas aeruginosa, that trouble people with cystic fibrosis (CF), a study suggests. The antibiotic molecule…
The Institute for Clinical and Economic Review (ICER) granted the therapy Trikafta the highest evidence rating (an “A”) for the treatment of cystic fibrosis (CF) in patients with either two copies the F508del mutation, or with one copy of the F508del mutation and a minimal function mutation in the…
The Cystic Fibrosis Foundation (CFF) is sponsoring free access to Beam, an online exercise platform that provides a variety of live and on-demand classes tailored for people with cystic fibrosis (CF), through Labor Day, Sept. 7. Complimentary registration through Beam’s website is available to adults with CF in the…
AzurRx BioPharma has been authorized to conduct its Phase 2b OPTION 2 clinical trial evaluating MS1819, its investigative therapy for exocrine pancreatic insufficiency (EPI) associated with cystic fibrosis (CF), at sites that are part of the Therapeutics Development Network (TDN). TDN is the largest network of…
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