News

Scientists have created a miniature human pancreas-on-a-chip that may help identify the cause of cystic fibrosis-related diabetes (CFRD), a common and life-threatening complication of cystic fibrosis (CF). Researchers believe the pancreas-on-a-chip will provide insightful information about the biology of CFRD, offering a reliable way to monitor pancreatic cell responses and…

Poorer lung function in pregnant women with cystic fibrosis (CF) is associated with a lower birth weight for offspring, and a higher likelihood of cesarean section — but not with changes in lung or metabolic parameters, new research suggests. The study, titled “Pregnancy outcome in women…

Oleh Taratula, PhD, a researcher at Oregon State University‘s College of Pharmacy, has been awarded a $2.3 million five-year grant to support a research project into a muscle-wasting disorder called cachexia that can affect people with chronic diseases that range from cancer to cystic fibrosis, multiple sclerosis, Crohn’s,…

Treating infants with cystic fibrosis (CF) with the antiviral therapy Synagis (palivizumab) does not improve long-term outcomes in lung health, real-world data show. Routine use of Synagis is not recommended by the American Academy of Pediatrics for babies with CF, although its use can be considered in those at…

Approved and investigative cystic fibrosis (CF) treatments known as CFTR potentiators work by binding to the same flexible protein spot — a place that acts like a hinge — and keeping it open, according to a study whose findings may lead to more effective therapies. The research, “Structural…

Eluforsen, an investigational therapy for the treatment of cystic fibrosis (CF), improves the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in cellular and mice models of CF that carry the most common mutation associated with the disorder, a study says. The findings of the study,…

AzurRx BioPharma has initiated a Phase 2 clinical trial testing its oral capsule MS1819-SD, combined with standard porcine pancreatic enzyme replacement therapy (PERT), in people with cystic fibrosis (CF) who have exocrine pancreatic insufficiency (EPI). PERT is the standard of care for EPI associated with…

People with cystic fibrosis (CF) may require a modified and more rigorous cleansing procedure to prepare their bowels for a colonoscopy screening procedure that allows good visualization, a study reports. Findings of the study, “A non-randomised single centre cohort study, comparing standard and modified bowel preparations, in adults with…

The diagnostic potential of breath analysis to detect serious lung infections in people with cystic fibrosis (CF) will be explored in a new clinical trial, which could lead to faster, more accurate diagnoses, and potentially improve the quality of life and prolong the life of these patients, researchers say. The…

Adding cystic-fibrosis-specific variables to the lung allocation score allows for more accurate identification of patients who are likely to benefit from a lung transplant, according to a new study. The study, titled “Effect of Including Important Clinical Variables on Accuracy of the Lung Allocation Score for Cystic…