News

A review study suggests that positive expiratory pressure (PEP) devices are more effective than other airway clearance approaches in reducing pulmonary exacerbations in patients with cystic fibrosis (CF), but of similar effectiveness in other measures, like lung function and mucus drainage. The study, entitled “Positive expiratory pressure physiotherapy for airway clearance in people with cystic…

A new study published in the journal e-LIFE has taken a novel approach to looking at deficits in protein folding associated with mutations in the CF transmembrane conductance regulator (CFTR) gene, the underlying cause of cystic fibrosis (CF). By identifying the signaling networks controlling protein folding, the study opens…

Cystic Fibrosis News Today has covered news of the latest treatments, events, clinical trials, and research updates in cystic fibrosis on a daily basis throughout the past year. As 2015 comes to an end, here are 10 articles most widely read by Cystic Fibrosis News Today readers, each with a brief summary of the developments that…

A new study of children with cystic fibrosis found that co-infection with methicillin-resistant bacteria may be associated with increased pulmonary morbidity, especially in children with repeat hospitalizations. The retrospective study, conducted at a U.S. pediatric medical center with high rates of methicillin-resistant respiratory infections, is titled “Clinical characteristics and…

In a new study, researchers investigated the CFTR gene locus (its location and position in DNA) and the role of elements involved in regulating the chromatin structure and gene expression, discovering a mechanism that coordinates these regulatory elements and maintains normal gene expression levels when structural perturbations occur. The findings…

A Case Western Reserve University researcher is starting two studies, based on angiotensin signaling and gene “correction,” to advance research into more effective ways of treating cystic fibrosis (CF) and to better understand the ideal timing for such interventions. Both studies will begin in January. CF is due to a defective gene that causes a thick buildup…

ProMetic Life Sciences Inc. announced plans to initiate a Phase 2 clinical trial to test its anti-fibrotic lead drug candidate PBI-4050 in cystic fibrosis (CF) patients with related diabetes as well as liver steatosis. Cystic fibrosis is a chronic disease of the lungs and, less frequently, of the pancreas, liver, kidneys, and gut,…

Ryan Kelly has been named the 17th football player to win the 2015 Rimington Trophy. The award, which was announced last Thursday on December 10 according to a recent press release, is given annually to the Most Outstanding Center in NCAA Division I-A College Football in the U.S., and is determined by a consensus of All-American…

New complexes of nickel (II) with imidazole derivatives were evaluated as potential treatment for P. aeruginosa biofilm eradication in cystic fibrosis. The study, titled “The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis” was published…

In a new study, researchers describe the results of a genome-wide screen of Pseudomonas aeruginosa in a yeast, which led to the identification of three potential new Pseudomonas virulence factors. The research paper, entitled “Genome-wide Screen of Pseudomonas aeruginosa in Saccharomyces cerevisiae Identifies New Virulence Factors,” was published in Frontiers in Cellular and…