News

The European Medicines Authority’s Committee for Orphan Medicinal Products (COMP) has issued a positive opinion recommending the designation of orphan medicinal product to Arch Biopartners Inc.‘s AB569 as a potential treatment of infections in cystic fibrosis (CF) patients. AB569 was invented at the University of Cincinnati (UC) in the laboratory…

A scientific paper published by Spanish researchers discusses a strategy for treating the difficult-to-target F508del-CFTR mutation, a cause of cystic fibrosis (CF). The report, “Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis,“ appeared on March 14 in the journal Molecular and Cellular Pediatrics. CF…

According to the study “The Role of Computed Tomography in Monitoring Patients with Cystic Fibrosis” published in the Polish Journal of Radiology, computed tomography (CT), an imaging technique that is commonly used for the evaluation of cystic fibrosis (CF) in individual patients, can play a critical…

Two Texas surgical teams recently performed an extremely rare, lungs-and-liver double organ transplant at the University of Texas (UT) Southwestern Medical Center’s William P. Clements Jr. University Hospital. The operation, the first successfully completed in North Texas and only the 75th such surgery in the United States,  gave 25-year-old Josiah…

A Chicago Medical School review explored the scientific evidence behind three natural compounds — genistein, curcumin, and resveratrol — often proposed for the treatment of cystic fibrosis (CF). The review concluded that while the mechanisms by which these substances function should be further investigated as potential drug treatments, there is little evidence…

The Cystic Fibrosis Foundation announced that it welcomes the recent creation of a Cystic Fibrosis Caucus in the U.S. Senate, several years after a similar caucus was established in the lower branch of the U.S. Congress, the House of Representatives. The foundation also thanked the bipartisan work of two…

Pulmatrix, Inc.’s chief scientific officer, Dr. David L. Hava, described in an article recent advances in drug delivery strategies — such as nebulizers for inhaled delivery  — that are helping to treat bacterial and fungal lung infections, and are particularly relevant to people with diseases like cystic fibrosis (CF). The article, “…

AmpliPhi Biosciences, a biotech company focused on the development and commercialization of novel bacteriophage-based antibacterial therapeutics, recently presented new data at the European Congress of Clinical Microbiology and Infectious Diseases about the in vitro and in vivo activity of its investigational phage mix AB-PA01. Chronic lung infections caused by Pseudomonas aeruginosa are a major…

TGV-Inhalonix announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug designation to its antimicrobial agent as a possible treatment for antibiotic-resistant bacterial lung infections in patients with cystic fibrosis (CF). Mul-1867 is a nebulized solution designed for easy self-administration. According to the company, it is the first inhaled antimicrobial being developed…

New research from the University of Iowa’s Pappajohn Biomedical Institute (PBI) suggested that the sticky mucus found in cystic fibrosis (CF) patients is more viscous than usual because the thin layer coating the airways is more acidic in these people, a finding that supports a current therapeutic approach for CF. The study, “Acidic…