In a new study, researchers investigated the CFTR gene locus (its location and position in DNA) and the role of elements involved in regulating the chromatin structure and gene expression, discovering a mechanism that coordinates these regulatory elements and maintains normal gene expression levels when structural perturbations occur. The findings…
A Case Western Reserve University researcher is starting two studies, based on angiotensin signaling and gene “correction,” to advance research into more effective ways of treating cystic fibrosis (CF) and to better understand the ideal timing for such interventions. Both studies will begin in January. CF is due to a defective gene that causes a thick buildup…
ProMetic Life Sciences Inc. announced plans to initiate a Phase 2 clinical trial to test its anti-fibrotic lead drug candidate PBI-4050 in cystic fibrosis (CF) patients with related diabetes as well as liver steatosis. Cystic fibrosis is a chronic disease of the lungs and, less frequently, of the pancreas, liver, kidneys, and gut,…
Ryan Kelly has been named the 17th football player to win the 2015 Rimington Trophy. The award, which was announced last Thursday on December 10 according to a recent press release, is given annually to the Most Outstanding Center in NCAA Division I-A College Football in the U.S., and is determined by a consensus of All-American…
New complexes of nickel (II) with imidazole derivatives were evaluated as potential treatment for P. aeruginosa biofilm eradication in cystic fibrosis. The study, titled “The effects of nickel(II) complexes with imidazole derivatives on pyocyanin and pyoverdine production by Pseudomonas aeruginosa strains isolated from cystic fibrosis” was published…
In a new study, researchers describe the results of a genome-wide screen of Pseudomonas aeruginosa in a yeast, which led to the identification of three potential new Pseudomonas virulence factors. The research paper, entitled “Genome-wide Screen of Pseudomonas aeruginosa in Saccharomyces cerevisiae Identifies New Virulence Factors,” was published in Frontiers in Cellular and…
Luanne McKinnon, like many cystic fibrosis (CF) patients, is a determined achiever who lives life to its fullest — even earning a doctorate in art history at age 60. Her story was the subject of a recent profile in The University of Virginia’s online newspaper, UVA Today. McKinnon, who was awarded her PhD…
The Boomer Esiason Foundation (BEF) recently launched an awareness campaign for Team Boomer, its effort to encourage the cystic fibrosis (CF) community to live a healthy and active lifestyle and gets athletes to join the fight. The current initiative includes an EHE International partnership that led to a prominent BEF holiday window display at Rockefeller…
Harvard Assets, a Pennsylvania-based provider of bullion and investment-grade diamond, recently renewed its support to the Cystic Fibrosis Foundation (CFF) and its mission of supporting the development of new drugs to fight cystic fibrosis (CF), improving the quality of life for those with the disease, and ultimately finding a cure. John Tucker,…
Nivalis Therapeutics, Inc., a Boulder, Colorado-based clinical stage pharmaceutical company, announced that the first patient has been dosed in the Phase 2 clinical trial of its lead investigational drug, N91115, a stabilizer of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The purpose of this double-blind, randomized, placebo-controlled, parallel group study…
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