The Cystic Fibrosis Foundation is funding three new early-stage research awards worth more than $1.8 million to bolster the development of potential gene therapies for cystic fibrosis (CF). “This funding will support critical early steps necessary for the development of genetic therapies for cystic fibrosis,” William Skach, MD, executive…
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The Cystic Fibrosis Foundation announced a $3.5 million investment in Pulmocide to support the company in developing an inhaled medication, opelconazole, to prevent fungal infections — specifically Aspergillus — in lung transplant patients. This funding will go toward a planned, multicenter Phase 2 clinical trial of opelconazole to…
In children with cystic fibrosis (CF), evidence of the bacteria Pseudomonas aeruginosa was associated with poorer lung function — based on predicted forced expiration volume in one second, FEV1% — while those testing positive for rhinovirus, which frequently causes the common cold, were more likely to have better…
Epithelial cells collected from the nasal passages and grown in the lab under a specialized protocol could be a useful model for studying the molecular underpinnings of cystic fibrosis (CF) and testing potential treatments, a study reported. The study, “Correlating genotype with phenotype using CFTR-mediated whole-cell…
A complete analysis of the CFTR gene, which is defective in cystic fibrosis (CF), identifies potential disease-causing mutations that would be missed by standard testing, as well as variations that may explain differences in disease course and treatment responses, a study of more than 5,000 CF patients shows. Still,…
Urinary incontinence, known to affect both girls and women with cystic fibrosis (CF), is increasingly prevalent as these patients age, and coughing or sneezing were common triggers among adults who took part in a study at a single site in Italy. Incontinence during physical exercise was also fairly common…
People with cystic fibrosis (CF) who score highly on measures of self-compassion tend also to report higher quality of life, a study found. “The current findings suggest that psychological interventions which increase self-compassion could be beneficial for enhancing better mental health and quality of life for adults with CF,”…
Inadequate nutrition, poorly working or chronically infected lungs, and mutations leading to more severe disease can shorten the lifespan of people with cystic fibrosis (CF), a study in adult patients reported. “All these factors interact with each other,” its scientists wrote. “Therefore, it is important to take into account…
Researchers generated functional bile duct cells from human-derived stem cells that can be used to support the development of therapies for liver disease in people with cystic fibrosis (CF), a study reported. “These studies highlight the importance of generating mature cells from stem cells that faithfully mimic the functional…
The microbiome diversity in the lungs of cystic fibrosis (CF) patients increased after treatment with Trikafta, becoming similar to a person without CF, an analysis showed. In addition, small molecule metabolites produced by cells varied widely across patients while on the therapy, with the largest decrease seen in…
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