Lindsey Shapiro, PhD, science writer —

Allergies to beta-lactam antibiotics were the most commonly confirmed antibiotic allergy in children with cystic fibrosis, according to a small study in Turkey. Sensitivity to multiple types of antibiotics occurred in one-third of children with an allergy, data showed. Having an immediate reaction to a medication and an allergy…

Lumacaftor (VX-809) — one of the medications in the CFTR modulator Orkambi —  led to a significant protein reorganization in two cellular compartments in a cell model of cystic fibrosis (CF), causing them to more closely resemble healthy cells, a study showed. The findings expand the potential mechanisms…

Destiny Pharma has received an award from the Cystic Fibrosis Foundation (CFF) to evaluate its investigational compound, XF-73, as a potential treatment for methicillin-resistant Staphylococcus aureus (MRSA) lung infections in people with cystic fibrosis (CF). The study will be carried out by researchers affiliated with the CFF,…

Researchers have developed a way to monitor the onset and progression of lung disease in young children with cystic fibrosis (CF) for whom lung imaging and diagnostic techniques are not well established. Testing the approach in 145 CF infants, the researchers found that about half showed signs of early-onset…

Six months of Kaftrio (elexacaftor-tezacaftor-ivacaftor), which is marketed as Trikafta in the U.S., led to marked reductions in abdominal symptoms among people with cystic fibrosis (CF), a study in Germany and the U.K. found. “To our knowledge, this is the first study assessing gastrointestinal symptoms, with a validated…

The prevalence of cystic fibrosis (CF), used as an indicator of the number of CF carriers, was correlated with rates of COVID-19 and related mortality during the pandemic’s early stages across 37 different countries, a study showed. “This report suggests a possible contribution of the CFTR genetic profile of…

Treatment with the antibiotic azithromycin did not prevent the development of lung damage in infants with cystic fibrosis (CF), but was safe and lowered inflammation, hospital stays and antibiotic usage, according to data from a Phase 3 clinical trial. “Azithromycin treatment from diagnosis of cystic fibrosis after newborn…

When an initial antibiotic failed to improve lung function with a pulmonary exacerbation, switching antibiotics did not lead to greater gains among adults or children with cystic fibrosis (CF), a study found. “It appears clear that regardless of antibiotic choice, there is a subset of patients who will be slow…

Treatment with Kalydeco (ivacaftor) led to improved lung function and weight gain as well as fewer respiratory infections and hospitalizations among cystic fibrosis (CF) patients with certain CFTR gating mutations, according to a real-world study. “These results support the long-term effectiveness and use of ivacaftor [Kalydeco] for the…

Researchers at Stanford University have been awarded £210,000 (about $265,000) to study preventing hearing loss caused by a class of antibiotics, called aminoglycosides, that are commonly used to treat lung infections in people with cystic fibrosis (CF). The three-year research project will be jointly funded by the Royal…