Lindsey Shapiro, PhD, science writer —

Children with cystic fibrosis (CF) show significant differences from healthy children in the quality of their food choices and, subsequently, the microbes in their gut and respiratory tract, with evidence of greater intestinal inflammation in these young patients, a recent study in Australia found. Certain microbes in the gut associated…

The first patient has been dosed in a Phase 1b/2 clinical trial testing WRAIR-PAM-CF1, an investigational bacteriophage therapy, in adult cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa lung infections. The PHAGE trial (NCT05453578) is recruiting an estimated 72 such patients who tested positive for a P. aeruginosa infection…

Renexxion is seeking clearance from the U.S. Food and Drug Administration (FDA) for clinical testing of the treatment candidate naronapride in people with cystic fibrosis (CF) and gastrointestinal (GI) problems. The Ireland-based biopharmaceutical company, which specializes in treatments for gastrointestinal disorders, announced the opening of an investigational new…

Cystic Fibrosis News Today brought you daily coverage of the latest scientific discoveries, treatment advances, and clinical trials related to cystic fibrosis (CF) this past year. We look forward to continuing to offer you the most up-to-date information in 2023. Here are the 10 most-read CF news articles of 2022,…

For a small group of people with cystic fibrosis (CF), one year of treatment with Orkambi (ivacaftor/lumacaftor) improved bone health and stabilized pancreatic function, nutritional status, reproductive hormone levels, and lung function. These findings from a recent study in Israel demonstrate the use of Orkambi, which targets the…

A recent overall decline in lung transplant rates for adults and children with cystic fibrosis (CF) in the U.S. has had less impact on nonwhite patients, according to a recent analysis. While transplant rates have decreased in the past couple years for all people with CF, the declines were…

Adding a school specialist to cystic fibrosis (CF) care teams could help identify educational risk factors — and provide interventions — to promote school success for children with CF, according to a new study. That study, by specialists at a CF center in Ohio, found that more than half…

High blood-sugar levels at night are associated with poorer lung function in adults, but not in children, with cystic fibrosis (CF), a study has found. During a week of continuous glucose monitoring, blood-sugar abnormalities were observed in almost all CF adults and children evaluated, even when other tests taken over the…

Children with cystic fibrosis (CF) being treated with Orkambi (ivacaftor/lumacaftor) have distinct clinical response profiles after six months of treatment in a real-world setting, a French-Italian study found. While changes in lung function were the largest driver of treatment responses in older children ages 12–18, body mass index…

Children who carry certain mutations associated with cystic fibrosis (CF), but do not have the disease — called CF carriers — may be more likely to develop asthma than children who don’t carry a mutation, a California study found. In particular, inheriting one copy of the most common CF-causing…