Marta Figueiredo, PhD,  science writer—

Exposure to carbon nanoparticles — tiny air pollution particles that account for a substantial part of air pollution in urban areas — significantly reduces the levels of CFTR, the faulty protein in cystic fibrosis (CF), according to the results of a new study. Being exposed to these air pollution…

Most military cystic fibrosis (CF) centers in the U.S. are generally following mental health screening guidelines — but there’s still room for improvement — a study showed. Specifically, the identified areas needing improvement include the standardized use of screening tools for suicidal thoughts, improving healthcare providers’ comfort with all…

Treatment with PP-007 — a compound known to promote the release of anti-inflammatory carbon monoxide (CO) gas — significantly reduced the levels of pro-inflammatory immune cells and molecules in the lungs of a mouse model of cystic fibrosis (CF), a study shows. These benefits were associated with an increased production…

A small compound called c407 restored the function of CFTR — the defective protein in cystic fibrosis (CF) — and its associated chloride flow in mice carrying F508del, the most common CF-causing mutation, a study shows. These benefits were associated with a stabilization of CFTR’s folding and its increased transport to the…

The frequency of cystic fibrosis-associated liver disease (CFLD) has increased in the past two decades and is linked to several simultaneous health complications, a U.S. study shows. CFLD was also found to be independently associated with a higher risk of mortality and increased healthcare resource use in children hospitalized due…

Cystic fibrosis (CF) patients with non-tuberculous mycobacteria (NTM) lung infection show significant changes in airway metabolites relative to those without such infections, a study shows. Metabolites are intermediate or end products of cellular metabolism, and some of these altered metabolites play roles in immune responses and bacterial growth. Combining…

A lung and pancreatic cell transplant from a single donor to people with end-stage cystic fibrosis (CF) and CF-related diabetes (CFRD) safely and effectively improved their lung function, metabolic control, and quality of life, data from a small Phase 1/2 trial show. Given that CFRD increases the risk of complications…

Adults with cystic fibrosis (CF) have significantly higher levels of anti-inflammatory oxylipins — a type of fatty molecule — and lower levels of pro-inflammatory fatty molecules in their saliva relative to healthy individuals, a study shows. This suggests a shift toward an anti-inflammatory response in the fatty molecule profile…

A noninvasive measure of lung function called lung clearance index (LCI) could be used to identify children and adolescents with cystic fibrosis (CF) who are at higher risk of a pulmonary exacerbation, an Italian study found. Notably, this work involved patients with normal or mildly reduced forced expiratory volume…

Multiple breath washout testing is superior to chest X-rays at detecting early signs of cystic fibrosis (CF) in infants and preschoolers, a study shows. The data also suggest that combining information from both techniques provides a considerable degree of assurance regarding the absence or potential presence of early lung…