Teresa Carvalho, MS, science writer —

A Phase 2 clinical trial of a new optimized formulation of adrulipase, a yeast-derived enzyme for treating exocrine pancreatic insufficiency (EPI) in adults with cystic fibrosis (CF), is about to start. First Wave BioPharma, its developer, anticipates patient screening will start early this month, with top-line results expected…

Living closer to composting sites, where solid urban waste is collected and stored, may increase the risk of more severe disease for adults with cystic fibrosis (CF), according to a U.K. study. Close proximity to such sites was linked with worse lung function and more fungal infections among adults. The…

The first participant has been dosed in a Phase 1 clinical trial evaluating Sionna Therapeutics‘ SION-638, an investigational oral treatment for cystic fibrosis (CF). The trial aims to assess the safety and pharmacokinetics — the movement into, through, and out of the body — of SION-638 in healthy volunteers.

CF Youth, a new exercise program created by Beam for children living with cystic fibrosis (CF), was launched on the company’s online platform. The initiative, created in collaboration with CF Yogi and Johns Hopkins Cystic Fibrosis Center, can be accessed by caregivers and healthcare providers. Regular exercise has been…

Women with cystic fibrosis (CF) who underwent a lung transplant are at higher risk of cervical dysplasia, or abnormal (precancerous) cells on the lower part of the uterus (cervix), a study reports. The risk increases among women who are not vaccinated against human papillomavirus (HPV), the main risk factor…

Horizon Therapeutics has launched its #RAREis Representation program aimed at increasing diversity, equity, and inclusion among patients with rare diseases. There are about 400 million people worldwide living with a rare disease; for many of them, access to diagnosis, care, and treatments can be challenging. Accessing better care depends on…

Nearly one-third of infants and toddlers with cystic fibrosis (CF) evaluated in a small study had low blood levels of zinc — a mineral whose insufficiency is associated with poor growth in otherwise healthy children. Still, the role of blood zinc levels “in growth and nutrition outcomes” for CF children…

Signs of lung disease were evident in most cystic fibrosis (CF) patients with normal lung function in a small study, and related with a higher number of pulmonary exacerbations and longer antibiotic use. These findings, based on a mix of lung health measures, indicate that such disease can precede changes…

Levels of neutrophil elastase, a pro-inflammatory enzyme normally released by immune cells known as neutrophils, plus a greater diversity and amount of microbes could drive disease severity in cystic fibrosis (CF), a study in two siblings suggests. The study, Two Siblings Homozygous for F508del-CFTR Have Varied…

The use of oral nutritional supplements is associated with a higher intake of nutrients and better levels of certain vitamins in cystic fibrosis (CF) patients with poor respiratory and nutritional status. These results are found in the study “Oral nutritional supplements in…