Author Archives: Vijaya Iyer, PhD

Vertex to Request Review of Orkambi, Symkevi Plus Kalydeco for Public Funding in Scotland

Vertex Pharmaceuticals has announced its intention to submit an application to the Scottish Medicines Consortium (SMC) to review the clinical and cost-effectiveness of the company’s cystic fibrosis (CF) medicines, Orkambi (lumacaftor/ivacaftor), as well as Symkevi (tezacaftor/ivacaftor) in combination with Kalydeco (ivacaftor). Following the appraisal of data submitted by…

#NACFC2018 – RPL554 Shows Promising Results in CF Studies

Positive data from preclinical and Phase 2a studies evaluating the investigational cystic fibrosis (CF) treatment RPL554 were presented at the 2018 North American Cystic Fibrosis Conference (NACFC) in Denver, Colorado (Oct. 18-20). RPL554, developed by Verona Pharma, is an inhaled potential therapy for CF and chronic obstructive pulmonary disease (COPD).

Researchers Find Way to Improve Antibiotics’ Efficacy Against Pseudomonas aeruginosa

Blocking superoxide dismutase, the enzyme that responds to stress, in Pseudomonas aeruginosa bacteria improves antibiotics’ efficacy, a Canadian study reported. The study, “Superoxide dismutase activity confers (p)ppGpp-mediated antibiotic tolerance to stationary-phase Pseudomonas aeruginosa,” was published in Proceedings of the National Academy of Sciences (PNAS). “We identified a new function important…

Vertex, Genomics Team Up in Quest for Genetics-based, Precision Medicines

Vertex Pharmaceuticals and Genomics announced a three-year collaboration to better understand genetic variations and their effect on clinical outcomes of diseases with unmet therapeutic needs, including cystic fibrosis. The collaboration also will promote the development of precision medicine, an approach to customize treatment based on each patient’s genetic…


Featured Column

Don’t Overlook Emotional Wellness When Dealing With Chronic Illness

A banner for Lara's column, depicting a car on a road trip winding through a forest.
Living with a chronic illness can affect emotional wellness, writes columnist Lara Govendo, who offers up some ideas for managing both.

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