French scientists have found that distinct patterns of DNA methylation — a type of chemical change that influences how genes are used without altering the underlying DNA sequence — are associated with cystic fibrosis (CF), and are also tied to lung function and CF-related diabetes in people with the…

In young children with cystic fibrosis (CF), treatment with Alyftrek (vanzacaftor/tezacaftor/deutivacaftor) may reverse a form of pancreatic damage previously thought irreversible. That’s according to Vertex Pharmaceuticals, Alyftrek’s developer, which presented new data at this year’s North American Cystic Fibrosis Conference (NACFC). “The data presented at NACFC underscore…

For most of my life, food was medicine. Living with cystic fibrosis (CF) and pancreatic insufficiency meant my body didn’t absorb fat the way it should. Because of that, I also didn’t properly absorb fat-soluble vitamins. From childhood, I was taught to eat more: bigger portions,…

One year of Trikafta treatment boosted work productivity and daily activities for people with cystic fibrosis (CF), a real-world study from Canada showed. The gains stemmed from improvements in lung function, physical functioning, and the ability to engage in daily responsibilities. “These findings suggest that the clinical benefits…

As a therapist who lives with cystic fibrosis (CF) and a double-lung transplant, I’m not immune to mental health struggles, and in my experience, it’s nearly impossible to talk about chronic illness without talking about mental health. For many years, I felt alone and separated from my peers, but…

Kaftrio, a CFTR modulator marketed as Trikafta (elexacaftor/tezacaftor/ivacaftor) in the U.S., was associated with improved lung function and nutritional status in a study. Researchers found only small changes in which microorganisms were present, but larger changes in their activity. Those larger changes included more microbial activity related to butyrate,…