Immune abnormalities linked to lung inflammation and damage in people with cystic fibrosis (CF) may begin early in life and persist despite treatment, a study in Australia suggested. The study, led by researchers at the Murdoch Children’s Research Institute (MCRI) and the Peter MacCallum Cancer Centre, found widespread abnormalities…

Fifty years ago, a cystic fibrosis (CF) diagnosis meant something very specific: a short life, mostly counted in hospital stays and loss. Parents received the diagnosis and were quietly told not to plan far ahead. There was no genetic map, no targeted therapy, and no database of mutations. Back…

I recently underwent surgery to clear up a sinus infection. Even though I had a double-lung transplant eight years ago, cystic fibrosis (CF) still often results in thick, sticky mucus clogging up my sinuses and becoming a breeding ground for germs. I’ve lost track of how many sinus…

Immune cells that patrol the lungs, called alveolar macrophages, may help sustain persistent inflammation in cystic fibrosis (CF), according to a new study. Researchers found that alveolar macrophages in people with CF differed from healthy cells, showing inflammatory activity, abnormal cholesterol handling, and altered communication with other immune cells…

When my late daughter, Jasmine, was diagnosed with cystic fibrosis in 1994, we had appointments to remember, medications to track, and other treatments that seemed to eat up every spare moment. I remember sitting at the kitchen table surrounded by prescription bottles and sticky notes, wondering how I would…

People with cystic fibrosis (CF) treated with CFTR modulators have a significantly lower risk of death than untreated patients, with an overall 66% lesser risk over eight years, according to a large U.S. registry study. The survival benefit was similar in magnitude in males and females. “Our study is…