Adding antifungal therapy to oral corticosteroids was not associated with additional benefits for people with cystic fibrosis (CF) being treated for allergic bronchopulmonary aspergillosis (ABPA), a large U.S. real-world study found. ABPA is a lung condition in which the immune system overreacts to the fungus Aspergillus fumigatus, causing allergic…

After living with cystic fibrosis for nearly four decades, I’ve learned valuable lessons about support people. Chronic illness is not for the faint of heart, and not everyone can hang out in the uncertainty with me. I’m so grateful for those who can, and who have shown me what…

Longtime readers may recall that my first job after college was as a researcher in a cystic fibrosis (CF) lab at Cincinnati Children’s Hospital Medical Center. It was a transformative and deeply informative period of my life. I learned in the lab how frustrating science can be. For…

Treatment with Trikafta (elexacaftor/tezacaftor/ivacaftor) eased sinus symptoms and helped stabilize weight without evidence of worsening lung function in people with cystic fibrosis (CF) who had received a lung transplant, a study found. The researchers said the findings show that Trikafta “can be safely incorporated into post–lung transplant care…

A metabolic pathway shared by lung cells and bacteria may help explain two major features of lung disease in people with cystic fibrosis (CF): the gradual thickening of the airways and persistent lung infections. Researchers found that lab-grown human airway cells carrying disease-causing mutations increase their production of pyrimidines,…

Adults with cystic fibrosis (CF) who spent more time in homes with elevated indoor fine-particle levels tended to show changes in circulating inflammatory signaling proteins, a pilot study found. Researchers measured more than 40 signaling proteins and found that a blood marker linked to tissue repair was significantly associated with…