Kaftrio, a CFTR modulator marketed as Trikafta (elexacaftor/tezacaftor/ivacaftor) in the U.S., was associated with improved lung function and nutritional status in a study. Researchers found only small changes in which microorganisms were present, but larger changes in their activity. Those larger changes included more microbial activity related to butyrate,…
Discussion
The genetic defect that causes cystic fibrosis (CF) may also directly contribute to the development of pancreatic cancer, a new study done in cell models suggests. Researchers found that pancreatic cancer cells carrying CF-causing mutations grow faster than cancer cells without these mutations, and this growth could be…
Discussion
At 55, and six years past a double-lung transplant, I sometimes catch myself marveling at how I’ve gotten this far with cystic fibrosis (CF). When I was a kid, nobody handed my family a map that stretched this far. Yet here I am, still learning how to live beyond…
Discussion
I used to measure my worth the way so many of us are brought up to do: by what I did and by how productive I was. Productivity is a conversation starter in most social circles. How much you’ve accomplished or how busy you are is celebrated like a badge…
Discussion
GLP-1 receptor agonists (GLP-1RAs), medications commonly used for diabetes and weight loss, may improve lung function in adults with cystic fibrosis-related diabetes (CFRD), according to a small, exploratory study from Australia. After one year of treatment, patients given a GLP-1RA in addition to insulin, the standard CFRD treatment, had significant…
Discussion
I love my job and find the work that I do fulfilling. It’s cool to be a pharmacist. That said, a major issue in healthcare right now is caregiver burnout. Providing round-the-clock care to someone who is sick can be exhausting. Hospitals have all kinds of initiatives designed to…
Discussion
The next-generation triple-combination CFTR modulator Alyftrek can be safely given to children with cystic fibrosis (CF) as young as 2, according to results from a Phase 3 clinical trial. Findings from the trial also suggest that Alyftrek can improve CFTR activity in kids who switch from the first-generation…
Becoming educated and informed about cystic fibrosis is a good first step. Here you’ll find general information about the disease, including diagnosis, symptoms, and causes.
It helps to know others have been where you are now. Here’s a collection of our columnists’ words of wisdom to help you along on your CF journey.
There is no cure for CF yet, but here you can find more information about current therapeutic approaches, as well as experimental treatments that are in the pipeline.
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