Children with cystic fibrosis (CF) on Kaftrio maintained stable lung function over one year despite reducing their use of hypertonic saline and other airway-clearance treatments, a study shows. The reduction was accompanied by fewer days of antibiotic use. Respiratory symptoms and airway bacteria also remained stable, suggesting that…

If you live with cystic fibrosis (CF), chances are you already know more about fall risks than most people twice your age. I certainly do, even six years after I had a double-lung transplant. When people think of CF, they usually focus only on the lungs. Most of this…

Sionna Therapeutics is planning a proof-of-concept Phase 2a clinical trial to test a combination of two experimental treatments for cystic fibrosis (CF). The trial, dubbed AscenSION CF, will enroll adults who carry two copies of F508del, the most common CF-causing mutation, and who are taking the approved…

Note: This column describes the author’s experiences with tacrolimus and prednisone. Not everyone will have the same response to treatment. Consult your doctor before starting or stopping a therapy. I’ve been dealing with a different and unexpected symptom these past eight months, one that’s challenged my pain threshold on a…

Over the last two months, cystic fibrosis (CF) has summoned challenges that caught me by surprise. First, my body betrayed me in a way I haven’t experienced in more than 20 years: My small intestine became obstructed. Weeks later, my betrayer was not physical, but logistical: An airline lost…

Splisense has begun testing its inhaled therapy SPL84 alongside standard treatment in adults with cystic fibrosis (CF) who carry a specific genetic mutation. This second phase of an ongoing Phase 2 clinical trial is evaluating whether SPL84 can offer extra benefits when paired with the approved…