People with cystic fibrosis (CF) taking Trikafta usually report notable improvements in their quality of life — even if they don’t show substantial gains in objective measures of lung function — soon after starting treatment with the approved oral medication. That’s according to a new real-world study, which…

Counseling is as routine for me as eating. Being born with cystic fibrosis and receiving a double-lung transplant led to recurring mental health struggles, including anxiety and depression, which require continual management. Therapy is one of the tools I use to respond. I began my college years as a young,…

The use of combined hormonal contraceptives by women with cystic fibrosis (CF) who are not taking CFTR modulators increases by 53% the risk of developing CF-related diabetes (CFRD), a study in the U.S. found. Conversely, combined hormonal contraceptive “use was not associated with increased CFRD incidence among modulator…

Every morning used to start the same way. My late daughter, Jasmine, would shuffle into the kitchen with wild-looking hair, rub the sleep from her eyes, and ask for applesauce with cinnamon. Before she could eat, though, she’d have to do her cystic fibrosis treatment regimen, which consisted of…

Respiratory symptoms are key drivers for starting Kaftrio (elexacaftor/tezacaftor/ivacaftor) among adults with cystic fibrosis (CF) who have stable, near-normal breathing ability, known as preserved lung function, a survey study in Europe has found. In surveying CF centers across the continent, the research team found that clinicians were more likely…

A therapy created using a miniaturized antibody can correct the functionality of the defective CFTR protein in people with cystic fibrosis (CF) caused by the F508del mutation. Preclinical data indicate that this nanobody can act in synergy with Trikafta (ivacaftor/tezacaftor/elexacaftor), an approved treatment for CF. In combination,…