News

The Cystic Fibrosis Foundation (CFF) will spend $100 million over the next five years to fund research aimed at fighting infections in patients with cystic fibrosis (CF) — a problem that seems destined to grow as patients live longer with the disease. The announcement came during the 32nd…

Two compounds that make up approved cystic fibrosis (CF) therapy Orkambi — lumacaftor and ivacaftor — may work more effectively in patients whose airways are inflamed, according to new research. By mimicking the inflamed CF airways of patients in the lab, researchers also established a new…

A therapy that involves a synthetic cationic antimicrobial peptide (CAP) can decrease Pseudomonas aeruginosa biofilm formation alone or in combination with another antimicrobial agent called tobramycin. Cystic fibrosis (CF) patients are susceptible to repeated bacterial infections. Infection with Pseudomonas aeruginosa (P. aeruginosa) is particularly harmful, since it has been shown to decrease…

Adding bicarbonate, a salt, to the culture medium of Pseudomonas aeruginosa and Staphylococcus aureus, two of the most common bacteria underlying lung infections in people with cystic fibrosis (CF), impairs the bacteria’s growth, a study shows. This finding supports the potential use of inhaled bicarbonate as a therapy for…

Researchers may have found a new way of treating antibiotic-resistant bacterial infections, specifically Pseudomonas aeruginosa, in the airways of patients with cystic fibrosis (CF), a study shows. In a preliminary Phase 1 trial, a single five-day…

The nutritional status of cystic fibrosis (CF) patients after a lung transplant — as assessed by body composition — is a strong predictor of lung function post-surgery, a study shows. The study, “Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis,” was published in the…

Corbus Pharmaceuticals has received a patent from the U.S. Patent and Trademark Office covering all compositions that comprise lenabasum and might be used to treat any fibrotic disease, including cystic fibrosis (CF), the company announced in a press release. This patent (No. 10,085,964) also covers lenabasum in potentially treating dermatomyositis…

Antibiotics lessen the diversity of microbes in the lungs of cystic fibrosis (CF) patients, and make these people more susceptible to infections with bacteria that are highly resistant to antibiotics, researchers reported. The study “Antibiotic multidrug resistance in the cystic fibrosis airway microbiome is associated with decreased diversity”…

Vertex Pharmaceuticals has entered a partnership with the Danish pharmaceutical organization Amgros to one day make Vertex’s cystic fibrosis (CF) therapies available for Danish patients. The collaboration was made through an access contract, a first-of-its-kind contract that gives Danish CF patients access to all Vertex’s current and future CF…

Decibel Therapeutics received worldwide, exclusive rights to develop and commercialize ORC-13661, Oricula Therapeutics’ investigational treatment to prevent hearing loss and balance disorders in patients taking high doses of aminoglycoside antibiotics, including cystic fibrosis (CF) patients. Under the terms of the agreement, Oricula will provide scientific…