Vertex Pharmaceuticals’ VX-659 or VX-445 in combination with Kalydeco (ivacaftor) and tezacaftor (VX-661) can improve the lung function of patients with cystic fibrosis (CF) with one or two copies of the CFTR F508del mutation, Phase 2 data shows. Updated results of the studies were discussed…
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Treatment with a combo of Proteostasis Therapeutics’ investigational CFTR modulator therapies — PTI-808, a potentiator, plus PTI-801, a corrector — can promote significant improvements in lung function and reduction of sweat chloride in patients with cystic fibrosis (CF), Phase 1 data show. So far in the Phase…
Santhera Pharmaceuticals’ investigative inhalation therapy for cystic fibrosis (CF), POL6014, has been favored for orphan drug designation within the European Union. A recommendation supporting the designation, which offers financial and regulatory incentives to develop treatments for rare diseases, was made by …
AzurRx BioPharma is planning a multi-center Phase 2 trial to be conducted in the United States and Europe to evaluate its lead candidate MS1819-SD as a treatment for patients with exocrine pancreatic insufficiency (EPI) due to cystic fibrosis (CF). This announcement follows the approval by the U.S. Food and…
The Cystic Fibrosis Foundation (CFF) will spend $100 million over the next five years to fund research aimed at fighting infections in patients with cystic fibrosis (CF) — a problem that seems destined to grow as patients live longer with the disease. The announcement came during the 32nd…
Two compounds that make up approved cystic fibrosis (CF) therapy Orkambi — lumacaftor and ivacaftor — may work more effectively in patients whose airways are inflamed, according to new research. By mimicking the inflamed CF airways of patients in the lab, researchers also established a new…
A therapy that involves a synthetic cationic antimicrobial peptide (CAP) can decrease Pseudomonas aeruginosa biofilm formation alone or in combination with another antimicrobial agent called tobramycin. Cystic fibrosis (CF) patients are susceptible to repeated bacterial infections. Infection with Pseudomonas aeruginosa (P. aeruginosa) is particularly harmful, since it has been shown to decrease…
Adding bicarbonate, a salt, to the culture medium of Pseudomonas aeruginosa and Staphylococcus aureus, two of the most common bacteria underlying lung infections in people with cystic fibrosis (CF), impairs the bacteria’s growth, a study shows. This finding supports the potential use of inhaled bicarbonate as a therapy for…
Researchers may have found a new way of treating antibiotic-resistant bacterial infections, specifically Pseudomonas aeruginosa, in the airways of patients with cystic fibrosis (CF), a study shows. In a preliminary Phase 1 trial, a single five-day…
The nutritional status of cystic fibrosis (CF) patients after a lung transplant — as assessed by body composition — is a strong predictor of lung function post-surgery, a study shows. The study, “Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis,” was published in the…
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