News

#ECFS2018 – AB-PA01, with Antibiotics, Shows Promise in Treating Drug-resistant Lung Infections in CF

AmpliPhi Biosciences’ investigative therapy AB-PA01, in combination with antibiotics, shows significant potential to treat multi-drug resistant Pseudomonas aeruginosa infection in cystic fibrosis (CF), according to the case report of a CF patient with recurrent pneumonia and pulmonary exacerbations. These positive early results further support the development of the treatment against…

#ECFS2018 – Orkambi Taken for 1 Year Returned Glucose Levels to Normal in Group of CF Patients in Study

One year of treatment with Orkambi (lumacaftor/ivacaftor) returned blood glucose (sugar) levels to normal in almost half of a small group of diabetic or glucose-intolerant cystic fibrosis (CF) patients, a study reports. These results were summarized in the presentation “Observational study of glucose tolerance abnormalities in patients with cystic…

#ECFS2018 – Potential CFTR Corrector PTI-801, Plus Orkambi, Seen to Treat CF Patients in Phase 1 Trial

Treatment for 14 days with Proteostasis Therapeutics’ PTI-801 in cystic fibrosis (CF) patients also being treated with Orkambi (lumacaftor/ivacaftor) led to statistically significant improvements in sweat chloride, body mass index, and rescued blood glucose levels in a subgroup of patients with diabetes, Phase 1 trial data show. PTI-801 is being…

#ECFS2018 – Kalydeco’s Benefits Include Lower Risk of Death and Pulmonary Flares, Real-world Data Shows

Real-world results from the largest analyses of Vertex Pharmaceutical’s cystic fibrosis’ treatment Kalydeco (ivacaftor) done in CF patients to date confirm the therapy’s ability to significantly lower the risks of mortality, transplants, hospitalization, and pulmonary exacerbations compared to untreated patients. These results were presented today at the 41st European Cystic…

#ECFS2018 — Next-Generation CFTR Correctors for Cystic Fibrosis Show Promise in Early Trial Data

Preliminary clinical trial data of three investigational next-generation CFTR correctors, being developed by Vertex Pharmaceuticals, provides the first demonstration of their potential to improve the outcome of cystic fibrosis (CF) patients. Trial findings were presented today at the 41st European Cystic Fibrosis Society (ECFS) Conference, taking place…

#ECFS2018 — Hard-to-Treat Infections May Not Impact Survival of CF Patients After Lung Transplant, Study Shows

One-year survival after a lung transplant of cystic fibrosis (CF) patients chronically infected with antibiotic-resistant bacteria is similar to those without infections, according to a retrospective analysis of data from the International Society of Heart and Lung Transplantation (ISHLT) Thoracic Transplant Registry. Results of the study were shared today…