News

Clinical Trial Planned for Cystic Fibrosis Bacteria Treatment AIR001

The University of Pittsburgh has agreed to conduct a Phase 1 and 2 clinical trial of Aries Pharmaceuticals‘ AIR001 for treating Pseudomonas aeruginosa bacteria infections in patients with cystic fibrosis (CF). Researchers from the university and the University of Pittsburgh Medical Center will work together on the open-label safety and proof-of-concept trial. Aries, a…

Vertex Acquiring Cystic Fibrosis Treatment CTP-656 from Concert Pharmaceuticals

Vertex Pharmaceuticals is acquiring CTP-656, a potentiator treatment for the protein that is defective in cystic fibrosis, from Concert Pharmaceuticals. CTP-656, a deuterium-modified version of the therapy ivacaftor, is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, meaning that it enhances the activity of the CFTR protein. CTP-656 has received…

Resunab Shows Potential in Treating Lung Inflammation in Preclinical Study

The investigative oral treatment Resunab (JBT-101) shows promise in easing inflammation mediated by immune cells in the lungs of cystic fibrosis (CF) patients, according to results of a preclinical study. Results from a Phase 2 study of the treatment’s safety and efficacy in patients are expected shortly. The preclinical findings will be presented at Research and Development…

Kalydeco Improves Lung Function in CF Patients But Doesn’t Destroy Bacteria, Study Finds

Kalydeco (ivacaftor) is known to increase the activity of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in cystic fibrosis (CF) patients. A new study says the drug also improves lung function and reduces inflammation, but does not eradicate Pseudomonas bacteria infection. The study, “Restoring CFTR Function Reduces Airway Bacteria…